TL-1238

TL-1238 (Substance 3393) is an extremely potent carbamate acetylcholinesterase inhibitor. It has been shown to be more potent than neostigmine.[2][3]

TL-1238

Names
IUPAC name 3-[(Dimethylcarbamoyl)oxy]-N,N-diethyl-N-methylanilinium iodide
Other names Substance 3393
Identifiers
CAS Number	6249-65-6
3D model (JSmol)	Interactive image
ChemSpider	21206
PubChem CID	22621
CompTox Dashboard (EPA)	DTXSID60978074
InChI InChI=1S/C14H23N2O2.HI/c1-6-16(5,7-2)12-9-8-10-13(11-12)18-14(17)15(3)4;/h8-11H,6-7H2,1-5H3;1H/q+1;/p-1 Key: HBVVWBFVSLUJNP-UHFFFAOYSA-M
SMILES CC[N+](C)(CC)c1cccc(c1)OC(=O)N(C)C.[I-]
Properties
Chemical formula	C14H23IN2O2
Molar mass	378.254 g·mol^−1
Hazards
Main hazards	Extremely toxic
Lethal dose or concentration (LD, LC):
LD50 (median dose)	60 μg/kg (mice, intravenous)[1] 175 μg/kg (mice, subcutaneous)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

See also

• Miotine
• Neostigmine
• T-1123

References

1. "ChemIDplus".
2. Bülbring, E; Chou, TC (March 1947). "The relative activity of prostigmine homologues and other substances as antagonists to tubocurarine". British Journal of Pharmacology and Chemotherapy. 2 (1): 8–22. doi:10.1111/j.1476-5381.1947.tb00316.x. PMC 1509759. PMID 19108106.
3. BLASCHKO, H; BULBRING, E; CHOU, TC (March 1949). "Tubocurarine antagonism and inhibition of cholinesterases". British Journal of Pharmacology and Chemotherapy. 4 (1): 29–32. doi:10.1111/j.1476-5381.1949.tb00512.x. PMC 1509899. PMID 18113150.