Ifetroban

Ifetroban is a potent and selective thromboxane receptor antagonist.[1]

Ifetroban

Identifiers
IUPAC name 3-[2-({(1S,2R,3S)-3-[4-(Pentylcarbamoyl)-1,3-oxazol-2-yl]-7-oxabicyclo[2.2.1]hept-2-yl}methyl)phenyl]propanoic acid
CAS Number	143443-90-7
PubChem CID	23724921
ChemSpider	58452
UNII	E833KT807K
KEGG	D04500
ChEMBL	ChEMBL2146062
CompTox Dashboard (EPA)	DTXSID40869931
Chemical and physical data
Formula	C25H32N2O5
Molar mass	440.540 g·mol^−1
3D model (JSmol)	Interactive image
SMILES O=C(NCCCCC)c1nc(oc1)[C@@H]4C2O[C@@H](CC2)[C@@H]4Cc3ccccc3CCC(=O)O

Synthesis

Ifetroban synthesis: Drugs Future (c.f. Lednicer book 6).

References

1. Dockens RC, Santone KS, Mitroka JG, Morrison RA, Jemal M, Greene DS, Barbhaiya RH (August 2000). "Disposition of radiolabeled ifetroban in rats, dogs, monkeys, and humans" (PDF). Drug Metabolism and Disposition. 28 (8): 973–80. PMID 10901709.