Mavacoxib

Mavacoxib (trade name Trocoxil) is a veterinary drug used to treat pain and inflammation in dogs with degenerative joint disease.[1] It acts as a COX-2 inhibitor.[2]

Mavacoxib

Clinical data
Trade names	Trocoxil
AHFS/Drugs.com	International Drug Names
ATCvet code	QM01AH92 (WHO)
Identifiers
CAS Number	170569-88-7
PubChem CID	9843089
ChemSpider	8018804
UNII	YFT7X7SR77
ChEBI	CHEBI:76207
CompTox Dashboard (EPA)	DTXSID90168880
ECHA InfoCard	100.248.948
Chemical and physical data
Formula	C16H11F4N3O2S
Molar mass	385.34 g·mol^−1
3D model (JSmol)	Interactive image
SMILES C1=CC(=CC=C1C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F)F
InChI InChI=1S/C16H11F4N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25) Key:TTZNQDOUNXBMJV-UHFFFAOYSA-N

Mavacoxib, along with other COX-2 selective inhibitors, celecoxib, valdecoxib, and parecoxib, were discovered by a team at the Searle division of Monsanto led by John Talley.[3][4]

References

1. European Public Assessment Report (EPAR): Trocoxil, European Medicines Agency
2. Cox SR, Lesman SP, Boucher JF, Krautmann MJ, Hummel BD, Savides M, et al. (October 2010). "The pharmacokinetics of mavacoxib, a long-acting COX-2 inhibitor, in young adult laboratory dogs". Journal of Veterinary Pharmacology and Therapeutics. 33 (5): 461–70. doi:10.1111/j.1365-2885.2010.01165.x. PMID 20840390.
3. Langreth R (June 23, 2003). "The Chemical Cobbler". Forbes.
4. "Dr. John Talley: 2001 St. Louis Awardee" (PDF). Chemical Bond. St. Louis Section, American Chemical Society. 52 (5): 2. May 2001. Archived from the original (PDF) on 15 April 2018.