Suprofen

Suprofen is a nonsteroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica[1] that was marketed as 1% eye drops under the trade name Profenal.

Suprofen

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Oral, eye drops
ATC code	M01AE07 (WHO)
Legal status
Legal status	Discontinued
Pharmacokinetic data
Protein binding	20%
Identifiers
IUPAC name (RS)-2-[4-(2-thienylcarbonyl)phenyl]propanoic acid
CAS Number	40828-46-4
PubChem CID	5359
IUPHAR/BPS	7298
DrugBank	DB00870
ChemSpider	5166
UNII	988GU2F9PE
KEGG	D00452
ChEBI	CHEBI:9362
ChEMBL	ChEMBL956
CompTox Dashboard (EPA)	DTXSID5045469
ECHA InfoCard	100.050.071
Chemical and physical data
Formula	C14H12O3S
Molar mass	260.31 g·mol^−1
3D model (JSmol)	Interactive image
SMILES O=C(c1ccc(cc1)C(C(=O)O)C)c2sccc2
InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17) Key:MDKGKXOCJGEUJW-UHFFFAOYSA-N
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Uses

Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.[3] This application has been discontinued as well, at least in the US.[4]

References

1. DE 2353357, Janssen PA, Van Daele GH, Boey JM, "Antiphlogistic aroyl-substituted phenylacetic acid derivatives", issued 1974
2. Nies AS (1988). "Renal effects of nonsteroidal anti-inflammatory drugs". Agents and Actions. Supplements. 24: 95–106. doi:10.1007/978-3-0348-9160-8_9. ISBN 978-3-0348-9931-4. PMID 3142236.
3. "Pharmacy Compounding". Guidance for FDA Staff and Industry Compliance Policy Guides Manual. U.S. Food and Drug Administration. Archived from the original on 1 January 2009.
4. "Suprofen ophthalmic". Drugs.com.