CHRNB3

Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene.[5][6] This gene has been identified as a candidate for predisposition to tobacco dependence.

CHRNB3
Identifiers
Aliases	CHRNB3, cholinergic receptor nicotinic beta 3 subunit
External IDs	OMIM: 118508 MGI: 106212 HomoloGene: 36035 GeneCards: CHRNB3
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.21 Start 42,697,366 bp[1] End 42,737,407 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 27,368,711 bp[2] End 27,399,730 bp[2]
Gene ontology Molecular function • channel activity • ion channel activity • extracellular ligand-gated ion channel activity • ligand-gated ion channel activity • acetylcholine-gated cation-selective channel activity • transmembrane signaling receptor activity • acetylcholine binding • acetylcholine receptor activity • drug binding Cellular component • integral component of membrane • postsynaptic membrane • membrane • cell membrane • synapse • cell junction • acetylcholine-gated channel complex • dopaminergic synapse • integral component of plasma membrane • neuron projection Biological process • response to nicotine • synaptic transmission, cholinergic • ion transport • neuromuscular synaptic transmission • signal transduction • postsynaptic potential • excitatory postsynaptic potential • cation transmembrane transport • ion transmembrane transport • regulation of synaptic vesicle exocytosis • chemical synaptic transmission • regulation of membrane potential • nervous system process • protein heterooligomerization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1142	108043
Ensembl	ENSG00000147432	ENSMUSG00000031492
UniProt	Q05901	Q8BMN3
RefSeq (mRNA)	NM_000749 NM_001347717	NM_027454 NM_173212
RefSeq (protein)	NP_000740 NP_001334646	NP_081730 NP_775304
Location (UCSC)	Chr 8: 42.7 – 42.74 Mb	Chr 8: 27.37 – 27.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Nicotinic acetylcholine receptor

References

1. GRCh38: Ensembl release 89: ENSG00000147432 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031492 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
6. "Entrez Gene: CHRNB3 cholinergic receptor, nicotinic, beta 3".

Further reading

• Green WN, Millar NS (1995). "Ion-channel assembly". Trends Neurosci. 18 (6): 280–7. doi:10.1016/0166-2236(95)93915-K. PMID 7571003.
• Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Reviews of Physiology, Biochemistry and Pharmacology. Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 147. pp. 1–46. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266.
• Willoughby JJ, Ninkina NN, Beech MM, et al. (1993). "Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit". Neurosci. Lett. 155 (2): 136–9. doi:10.1016/0304-3940(93)90691-D. PMID 7690916. S2CID 39225391.
• Koyama K, Sudo K, Nakamura Y (1994). "Mapping of the human nicotinic acetylcholine receptor beta 3 gene (CHRNB3) within chromosome 8p11.2". Genomics. 21 (2): 460–1. doi:10.1006/geno.1994.1300. PMID 8088849.
• Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617. S2CID 45737923.
• Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220. S2CID 82364119.
• Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand). 43 (3): 433–42. PMID 9193799.
• Groot-Kormelink PJ, Luyten WH, Colquhoun D, Sivilotti LG (1998). "A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor". J. Biol. Chem. 273 (25): 15317–20. doi:10.1074/jbc.273.25.15317. PMID 9624109.
• Sato KZ, Fujii T, Watanabe Y, et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173. S2CID 43548155.
• Boorman JP, Groot-Kormelink PJ, Sivilotti LG (2001). "Stoichiometry of human recombinant neuronal nicotinic receptors containing the β3 subunit expressed in Xenopus oocytes". J. Physiol. 529 Pt 3 (Pt 3): 565–77. doi:10.1111/j.1469-7793.2000.00565.x. PMC 2270211. PMID 11118490.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Boorman JP, Beato M, Groot-Kormelink PJ, et al. (2004). "The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors". J. Biol. Chem. 278 (45): 44033–40. doi:10.1074/jbc.M211719200. PMID 12912995.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• CHRNB3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CHRNB3 genome location and CHRNB3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.