GRID1

Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a protein[5][6] that in humans is encoded by the GRID1 gene.[7][8]

GRID1
Identifiers
Aliases	GRID1, GluD1, glutamate ionotropic receptor delta type subunit 1
External IDs	OMIM: 610659 MGI: 95812 HomoloGene: 69017 GeneCards: GRID1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.1-q23.2 Start 85,599,552 bp[1] End 86,366,795 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 B|14 20.84 cM Start 34,820,108 bp[2] End 35,583,379 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ion channel activity • extracellular-glutamate-gated ion channel activity • ionotropic glutamate receptor activity • glutamate receptor activity • signaling receptor activity • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component • integral component of membrane • cell junction • postsynaptic membrane • cell membrane • synapse • extracellular exosome • membrane • glutamatergic synapse • integral component of postsynaptic density membrane Biological process • social organism behavior • ion transmembrane transport • ionotropic glutamate receptor signaling pathway • ion transport • excitatory postsynaptic potential • transport • synaptic transmission, glutamatergic • modulation of chemical synaptic transmission • postsynaptic potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2894	14803
Ensembl	ENSG00000182771	ENSMUSG00000041078
UniProt	Q9ULK0	Q61627
RefSeq (mRNA)	NM_017551	NM_008166
RefSeq (protein)	NP_060021	NP_032192
Location (UCSC)	Chr 10: 85.6 – 86.37 Mb	Chr 14: 34.82 – 35.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a subunit of glutamate receptor ligand-gated ion channel. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[7]

Clinical significance

Several genetic epidemiology studies have shown a strong association between several variants of the GRID1 gene and increased risk of developing schizophrenia.[9][10]

See also

• GRID2

References

1. GRCh38: Ensembl release 89: ENSG00000182771 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041078 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yamazaki M, Araki K, Shibata A, Mishina M (March 1992). "Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family". Biochem. Biophys. Res. Commun. 183 (2): 886–92. doi:10.1016/0006-291X(92)90566-4. PMID 1372507.
6. Treadaway J, Zuo J (December 1998). "Mapping of the mouse glutamate receptor delta1 subunit (Grid1) to chromosome 14". Genomics. 54 (2): 359–60. doi:10.1006/geno.1998.5599. PMID 9828146.
7. "Entrez Gene: GRID1 glutamate receptor, ionotropic, delta 1".
8. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
9. Guo SZ, Huang K, Shi YY, Tang W, Zhou J, Feng GY, Zhu SM, Liu HJ, Chen Y, Sun XD, He L (July 2007). "A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population". Schizophr. Res. 93 (1–3): 385–90. doi:10.1016/j.schres.2007.03.007. PMID 17490860. S2CID 9497500.
10. Treutlein J, Mühleisen TW, Frank J, Mattheisen M, Herms S, Ludwig KU, Treutlein T, Schmael C, Strohmaier J, Bösshenz KV, Breuer R, Paul T, Witt SH, Schulze TG, Schlösser RG, Nenadic I, Sauer H, Becker T, Maier W, Cichon S, Nöthen MM, Rietschel M (June 2009). "Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter". Schizophr. Res. 111 (1–3): 123–30. doi:10.1016/j.schres.2009.03.011. PMID 19346103. S2CID 20949145.

Further reading

• Fallin MD, Lasseter VK, Avramopoulos D, et al. (2006). "Bipolar I Disorder and Schizophrenia: A 440–Single-Nucleotide Polymorphism Screen of 64 Candidate Genes among Ashkenazi Jewish Case-Parent Trios". Am. J. Hum. Genet. 77 (6): 918–36. doi:10.1086/497703. PMC 1285177. PMID 16380905.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yue Z, Horton A, Bravin M, et al. (2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9. PMID 12372286. S2CID 10534933.
• Ly CD, Roche KW, Lee HK, Wenthold RJ (2002). "Identification of rat EMAP, a delta-glutamate receptor binding protein". Biochem. Biophys. Res. Commun. 291 (1): 85–90. doi:10.1006/bbrc.2002.6413. PMID 11829466.
• Roche KW, Ly CD, Petralia RS, et al. (1999). "Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses". J. Neurosci. 19 (10): 3926–34. doi:10.1523/JNEUROSCI.19-10-03926.1999. PMC 6782719. PMID 10234023.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.