GRINL1A

GRINL1A complex locus protein 1 is a protein that in humans is encoded by the GRINL1A gene.[5]

POLR2M
Identifiers
Aliases	POLR2M, GCOM1, GRINL1A, Gdown, Gdown1, polymerase (RNA) II subunit M, RNA polymerase II subunit M
External IDs	OMIM: 606485 MGI: 107282 HomoloGene: 9181 GeneCards: POLR2M
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.3 Start 57,706,695 bp[1] End 57,782,762 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 D|9 39.85 cM Start 71,478,437 bp[2] End 71,485,935 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA-directed 5'-3' RNA polymerase activity • GO:0001948 protein binding Cellular component • DNA-directed RNA polymerase II, holoenzyme • neuronal cell body • nuclear envelope • cell nucleus • cytoplasm • cell junction • cell membrane • Z disc • cytoskeleton • membrane • I band • cortical actin cytoskeleton • extrinsic component of cytoplasmic side of plasma membrane • intracellular Biological process • maintenance of ER location • RNA biosynthetic process • GO:0007243 intracellular signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81488	28015
Ensembl	ENSG00000255529	ENSMUSG00000032199
UniProt	P0CAP2 Q6EEV4 P0CAP1	Q6P6I6
RefSeq (mRNA)	NM_001018102 NM_015532	NM_001164793 NM_178602
RefSeq (protein)	NP_001018112 NP_056347 NP_001018112.1 NP_056347.1 NP_001018110 NP_689664	NP_001158265 NP_848717
Location (UCSC)	Chr 15: 57.71 – 57.78 Mb	Chr 9: 71.48 – 71.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene (GRINL1A) is part of a complex transcript unit that includes the gene for GRINL1A combined protein (Gcom1). Transcription of this gene occurs at a downstream promoter, with at least three different alternatively spliced variants, grouped together as Gdown for GRINL1A downstream transcripts. The Gcom1 gene uses an upstream promoter for transcription and also has multiple alternatively spliced variants.[5]

See also

• NMDA receptor

References

1. GRCh38: Ensembl release 89: ENSG00000255529 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032199 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GRINL1A glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Roginski RS, Mohan Raj BK, Finkernagel SW, Sciorra LJ (2001). "Assignment of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1 by in situ hybridization". Cytogenet. Cell Genet. 93 (1–2): 143–4. doi:10.1159/000056971. PMID 11474202.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Roginski RS, Mohan Raj BK, Birditt B, Rowen L (2005). "The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes". Genomics. 84 (2): 265–76. doi:10.1016/j.ygeno.2004.04.004. PMID 15233991.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

• GRINL1A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)