GLRB

Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.[5][6][7]

GLRB
Identifiers
Aliases	GLRB, HKPX2, glycine receptor beta
External IDs	OMIM: 138492 MGI: 95751 HomoloGene: 20224 GeneCards: GLRB
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q32.1 Start 157,076,125 bp[1] End 157,172,090 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 E3|3 35.71 cM Start 80,843,599 bp[2] End 80,913,660 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • glycine binding • GO:0001948 protein binding • drug binding • extracellular-glycine-gated ion channel activity • chloride channel activity • extracellular ligand-gated ion channel activity • extracellular-glycine-gated chloride channel activity • ion channel activity • transmembrane signaling receptor activity • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component • cytoplasm • integral component of membrane • postsynaptic membrane • cell projection • membrane • synapse • chloride channel complex • glycine-gated chloride channel complex • cell junction • dendrite • integral component of plasma membrane • cell membrane • GABA-ergic synapse • glycinergic synapse • neuron projection Biological process • response to amino acid • startle response • protein heterooligomerization • regulation of membrane potential • gamma-aminobutyric acid receptor clustering • chloride transmembrane transport • nervous system development • acrosome reaction • neuromuscular process • righting reflex • chloride transport • neuropeptide signaling pathway • visual perception • adult walking behavior • ion transport • synaptic transmission, glycinergic • excitatory postsynaptic potential • chemical synaptic transmission • ion transmembrane transport • signal transduction • nervous system process • postsynaptic potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2743	14658
Ensembl	ENSG00000109738	ENSMUSG00000028020
UniProt	P48167	P48168
RefSeq (mRNA)	NM_000824 NM_001166060 NM_001166061	NM_001281969 NM_010298 NM_001345955 NM_001345956 NM_001345957 NM_001345958 NM_001345959 NM_001345996
RefSeq (protein)	NP_000815 NP_001159532 NP_001159533	NP_001268898 NP_001332884 NP_001332885 NP_001332886 NP_001332887 NP_001332888 NP_001332925 NP_034428
Location (UCSC)	Chr 4: 157.08 – 157.17 Mb	Chr 3: 80.84 – 80.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM][7]

See also

• Glycine receptor

References

1. GRCh38: Ensembl release 89: ENSG00000109738 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028020 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Milani N, Mulhardt C, Weber RG, Lichter P, Kioschis P, Poustka A, Becker CM (Oct 1998). "The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism". Genomics. 50 (3): 341–5. doi:10.1006/geno.1998.5324. PMID 9676428.
6. Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR (Oct 1996). "The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes". Brain Res Mol Brain Res. 35 (1–2): 211–9. doi:10.1016/0169-328x(95)00218-h. PMID 8717357.
7. "Entrez Gene: GLRB glycine receptor, beta".

Further reading

• Meyer G, Kirsch J, Betz H, Langosch D (1995). "Identification of a gephyrin binding motif on the glycine receptor beta subunit". Neuron. 15 (3): 563–72. doi:10.1016/0896-6273(95)90145-0. PMID 7546736. S2CID 10164739.
• Sarang SS, Miller GW, Grant DF, Schnellmann RG (1999). "Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys". Nephron. 82 (3): 254–60. doi:10.1159/000045410. PMID 10395998. S2CID 382638.
• Rees MI, Lewis TM, Kwok JB, et al. (2002). "Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB)". Hum. Mol. Genet. 11 (7): 853–60. doi:10.1093/hmg/11.7.853. PMID 11929858.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chen Z, Dillon GH, Huang R (2004). "Molecular determinants of proton modulation of glycine receptors". J. Biol. Chem. 279 (2): 876–83. doi:10.1074/jbc.M307684200. PMID 14563849.
• Burzomato V, Groot-Kormelink PJ, Sivilotti LG, Beato M (2004). "Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation". Recept. Channels. 9 (6): 353–61. doi:10.3109/714041016. PMID 14698963.
• Harvey K, Duguid IC, Alldred MJ, et al. (2004). "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering" (PDF). J. Neurosci. 24 (25): 5816–26. doi:10.1523/JNEUROSCI.1184-04.2004. PMC 6729214. PMID 15215304.
• Grudzinska J, Schemm R, Haeger S, et al. (2005). "The beta subunit determines the ligand binding properties of synaptic glycine receptors". Neuron. 45 (5): 727–39. doi:10.1016/j.neuron.2005.01.028. PMID 15748848. S2CID 2778607.

External links

• GLRB+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.