P2RX6

P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene.[5][6][7][8]

P2RX6
Identifiers
Aliases	P2RX6, P2RXL1, P2X6, P2XM, purinergic receptor P2X 6
External IDs	OMIM: 608077 MGI: 1337113 HomoloGene: 3975 GeneCards: P2RX6
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 21,009,808 bp[1] End 21,028,830 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 17,561,885 bp[2] End 17,577,800 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • channel activity • purinergic nucleotide receptor activity • extracellular ATP-gated cation channel activity • ion channel activity • identical protein binding • ATP binding • transmembrane signaling receptor activity • ATP-gated ion channel activity Cellular component • cytoplasm • integral component of membrane • membrane • integral component of nuclear inner membrane • integral component of plasma membrane • cell junction • cell membrane • postsynapse • GO:0097483, GO:0097481 postsynaptic density • neuronal cell body • dendritic spine • parallel fiber to Purkinje cell synapse • glutamatergic synapse • integral component of postsynaptic specialization membrane Biological process • response to ATP • muscle contraction • ion transport • cation transmembrane transport • protein homooligomerization • signal transduction • blood coagulation • purinergic nucleotide receptor signaling pathway • excitatory postsynaptic potential • protein heterooligomerization • cation transport • ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9127	18440
Ensembl	ENSG00000099957	ENSMUSG00000022758
UniProt	O15547	O54803
RefSeq (mRNA)	NM_001159554 NM_005446 NM_001349874 NM_001349875 NM_001349876	NM_001159561 NM_011028
RefSeq (protein)	NP_001153026 NP_005437 NP_001336803 NP_001336804 NP_001336805	NP_001153033 NP_035158
Location (UCSC)	Chr 22: 21.01 – 21.03 Mb	Chr 16: 17.56 – 17.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.[8]

See also

• Purinergic receptor

References

1. GRCh38: Ensembl release 89: ENSG00000099957 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022758 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T (Sep 1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53". Cancer Res. 57 (15): 3281–7. PMID 9242461.
6. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
7. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (Sep 1996). "Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels". J Neurosci. 16 (8): 2495–507. PMID 8786426.
8. "Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor".

Further reading

• Khakh BS, Burnstock G, Kennedy C, et al. (2001). "International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits". Pharmacol. Rev. 53 (1): 107–18. PMID 11171941.
• Soto F, Garcia-Guzman M, Karschin C, Stühmer W (1996). "Cloning and tissue distribution of a novel P2X receptor from rat brain". Biochem. Biophys. Res. Commun. 223 (2): 456–60. doi:10.1006/bbrc.1996.0915. PMID 8670303.
• Glass R, Loesch A, Bodin P, Burnstock G (2002). "P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells". Cell. Mol. Life Sci. 59 (5): 870–81. doi:10.1007/s00018-002-8474-y. PMID 12088286.
• Maguire PB, Wynne KJ, Harney DF, et al. (2003). "Identification of the phosphotyrosine proteome from thrombin activated platelets". Proteomics. 2 (6): 642–8. doi:10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I. PMID 12112843.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrera NP, Ormond SJ, Henderson RM, et al. (2005). "Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize". J. Biol. Chem. 280 (11): 10759–65. doi:10.1074/jbc.M412265200. PMID 15657042.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• P2RXL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.