DUSP22

Dual specificity protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP22 gene.[5][6][7]

DUSP22
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WRM, 4WOH
Identifiers
Aliases	DUSP22, JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX, dual specificity phosphatase 22
External IDs	OMIM: 616778 MGI: 1915926 HomoloGene: 86039 GeneCards: DUSP22
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p25.3 Start 291,630 bp[1] End 351,355 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.2 Start 30,659,999 bp[2] End 30,711,231 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein tyrosine phosphatase activity • phosphatase activity • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • non-membrane spanning protein tyrosine phosphatase activity • protein tyrosine kinase binding Cellular component • cytoplasm • cell nucleus • cytosol • cell membrane • filamentous actin • leading edge of lamellipodium Biological process • multicellular organism development • inactivation of MAPK activity • negative regulation of T cell mediated immunity • protein dephosphorylation • peptidyl-tyrosine dephosphorylation • cellular proliferation • negative regulation of T cell activation • negative regulation of transcription from RNA polymerase II promoter • transforming growth factor beta receptor signaling pathway • regulation of cell proliferation • positive regulation of JNK cascade • negative regulation of T cell receptor signaling pathway • dephosphorylation • apoptotic process • negative regulation of cell migration • negative regulation of focal adhesion assembly • cellular response to epidermal growth factor stimulus • negative regulation of non-membrane spanning protein tyrosine kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56940	105352
Ensembl	ENSG00000112679	ENSMUSG00000069255
UniProt	Q9NRW4	Q99N11
RefSeq (mRNA)	NM_001286555 NM_020185	NM_001037955 NM_134068
RefSeq (protein)	NP_001273484 NP_064570	NP_001033044 NP_598829
Location (UCSC)	Chr 6: 0.29 – 0.35 Mb	Chr 13: 30.66 – 30.71 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

DUSP22 has been shown to interact with MAPK1[8] and MAPK8.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000112679 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000069255 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A (Sep 1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)". Genomics. 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128.
6. Shen Y, Luche R, Wei B, Gordon ML, Diltz CD, Tonks NK (Nov 2001). "Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1". Proc Natl Acad Sci U S A. 98 (24): 13613–8. Bibcode:2001PNAS...9813613S. doi:10.1073/pnas.231499098. PMC 61089. PMID 11717427.
7. "Entrez Gene: DUSP22 dual specificity phosphatase 22".
8. Aoyama, K; Nagata M; Oshima K; Matsuda T; Aoki N (Jul 2001). "Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain". J. Biol. Chem. 276 (29): 27575–83. doi:10.1074/jbc.M100408200. ISSN 0021-9258. PMID 11346645.

Further reading

• Aoyama K, Nagata M, Oshima K, et al. (2001). "Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain". J. Biol. Chem. 276 (29): 27575–83. doi:10.1074/jbc.M100408200. PMID 11346645.
• Alonso A, Merlo JJ, Na S, et al. (2002). "Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR)". J. Biol. Chem. 277 (7): 5524–8. doi:10.1074/jbc.M107653200. PMID 11733513.
• Chen AJ, Zhou G, Juan T, et al. (2002). "The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway". J. Biol. Chem. 277 (39): 36592–601. doi:10.1074/jbc.M200453200. PMID 12138158.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Alonso A, Narisawa S, Bogetz J, et al. (2004). "VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX". J. Biol. Chem. 279 (31): 32586–91. doi:10.1074/jbc.M403442200. PMID 15138252.
• Fortna A, Kim Y, MacLaren E, et al. (2004). "Lineage-specific gene duplication and loss in human and great ape evolution". PLOS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yokota T, Nara Y, Kashima A, et al. (2007). "Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution". Proteins. 66 (2): 272–8. doi:10.1002/prot.21152. PMID 17068812. S2CID 26785784.
• Sekine Y, Ikeda O, Hayakawa Y, et al. (2007). "DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118". Oncogene. 26 (41): 6038–49. doi:10.1038/sj.onc.1210426. PMID 17384676.
• Mélard P, Idrissi Y, Andrique L, et al. (2016). "Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes". Oncotarget. 7 (42): 68734–48. doi:10.18632/oncotarget.11930. PMC 5356586. PMID 27626696.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 22