PTPN23

Tyrosine-protein phosphatase non-receptor type 23 is an enzyme that in humans is encoded by the PTPN23 gene.[5][6]

PTPN23
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RAU, 5CRV, 5CRU
Identifiers
Aliases	PTPN23, HD-PTP, HDPTP, PTP-TD14, protein tyrosine phosphatase, non-receptor type 23, protein tyrosine phosphatase non-receptor type 23, NEDBASS
External IDs	OMIM: 606584 MGI: 2144837 HomoloGene: 135706 GeneCards: PTPN23
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 47,381,011 bp[1] End 47,413,435 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F2 Start 110,385,082 bp[2] End 110,408,213 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phosphoprotein phosphatase activity • phosphatase activity • GO:0001948 protein binding • protein tyrosine phosphatase activity • protein kinase binding • hydrolase activity Cellular component • cytoplasm • ciliary basal body • endosome • cell projection • cilium • nucleoplasm • early endosome • extracellular exosome • cytoskeleton • cytoplasmic vesicle • cell nucleus • nuclear body • cytosol Biological process • positive regulation of homophilic cell adhesion • cilium morphogenesis • regulation of cell migration • protein dephosphorylation • positive regulation of adherens junction organization • cell projection organization • protein transport • positive regulation of early endosome to late endosome transport • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • negative regulation of epithelial cell migration • dephosphorylation • peptidyl-tyrosine dephosphorylation • early endosome to late endosome transport • positive regulation of Wnt protein secretion • transport • endocytic recycling • cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25930	104831
Ensembl	ENSG00000076201	ENSMUSG00000036057
UniProt	Q9H3S7	Q6PB44
RefSeq (mRNA)	NM_001304482 NM_015466	NM_001081043
RefSeq (protein)	NP_001291411 NP_056281	NP_001074512
Location (UCSC)	Chr 3: 47.38 – 47.41 Mb	Chr 9: 110.39 – 110.41 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000076201 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036057 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Toyooka S, Ouchida M, Jitsumori Y, Tsukuda K, Sakai A, Nakamura A, Shimizu N, Shimizu K (Dec 2000). "HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3". Biochem Biophys Res Commun. 278 (3): 671–8. doi:10.1006/bbrc.2000.3870. PMID 11095967.
6. "Entrez Gene: PTPN23 protein tyrosine phosphatase, non-receptor type 23".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mariotti M, Castiglioni S, Maier JA (2006). "Expression analysis and modulation by HIV-Tat of the tyrosine phosphatase HD-PTP". J. Cell. Biochem. 98 (2): 301–8. doi:10.1002/jcb.20770. PMID 16408268. S2CID 9546573.
• Mariotti M, Castiglioni S, Beguinot L, Maier JA (2006). "The tyrosine phosphatase HD-PTP is regulated by FGF-2 through proteasome degradation" (PDF). Front. Biosci. 11: 2138–43. doi:10.2741/1956. PMID 16720300.
• Castiglioni S, Maier JA, Mariotti M (2007). "The tyrosine phosphatase HD-PTP: A novel player in endothelial migration". Biochem. Biophys. Res. Commun. 364 (3): 534–9. doi:10.1016/j.bbrc.2007.10.022. PMID 17959146.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9H3S7 (Human Tyrosine-protein phosphatase non-receptor type 23 (PTPN23)) at the PDBe-KB.