PTPRD

Receptor-type tyrosine-protein phosphatase delta is an enzyme that, in humans, is encoded by the PTPRD gene.[3][4][5]

PTPRD
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1X5Z, 2DLH, 2YD6, 2YD7, 4RCA
Identifiers
Aliases	PTPRD, HPTP, HPTPD, HPTPDELTA, PTPD, RPTPDELTA, protein tyrosine phosphatase, receptor type D, protein tyrosine phosphatase receptor type D, R-PTP-delta
External IDs	OMIM: 601598 HomoloGene: 88669 GeneCards: PTPRD
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p24.1-p23 Start 8,314,246 bp[1] End 10,612,723 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transmembrane receptor protein tyrosine phosphatase activity • phosphoprotein phosphatase activity • protein tyrosine phosphatase activity • hydrolase activity • receptor binding • cell adhesion molecule binding • phosphatase activity • GO:0001948 protein binding Cellular component • extracellular exosome • membrane • integral component of membrane • integral component of plasma membrane • cell membrane • glutamatergic synapse Biological process • presynaptic membrane assembly • transmembrane receptor protein tyrosine phosphatase signaling pathway • neuron differentiation • positive regulation of dendrite morphogenesis • protein dephosphorylation • phosphate-containing compound metabolic process • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • dephosphorylation • peptidyl-tyrosine dephosphorylation • positive regulation of synapse assembly • regulation of postsynaptic density assembly • trans-synaptic signaling by trans-synaptic complex • synaptic membrane adhesion • regulation of presynapse assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5789	n/a
Ensembl	ENSG00000153707 ENSG00000282932	n/a
UniProt	P23468 Q3KPI9	n/a
RefSeq (mRNA)	NM_001040712 NM_001171025 NM_002839 NM_130391 NM_130392 NM_130393 NM_001377946 NM_001377947 NM_001377958 NM_001378058	n/a
RefSeq (protein)	NP_001035802 NP_001164496 NP_002830 NP_569075 NP_569076 NP_569077 NP_001364875 NP_001364876 NP_001364887 NP_001364987 NP_569077.2	n/a
Location (UCSC)	Chr 9: 8.31 – 10.61 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple tissue specific alternatively spliced transcript variants of this gene have been reported.[5]

Clinical significance

Mutations in the PTPRD gene are associated with autism,[6] obsessive–compulsive disorder,[7] and breast cancer.[8]

Interactions

PTPRD has been shown to interact with PTPRS[9] and liprin-alpha-1.[10]

References

1. ENSG00000282932 GRCh38: Ensembl release 89: ENSG00000153707, ENSG00000282932 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Pulido R, Krueger NX, Serra-Pagès C, Saito H, Streuli M (Apr 1995). "Molecular characterization of the human transmembrane protein-tyrosine phosphatase delta. Evidence for tissue-specific expression of alternative human transmembrane protein-tyrosine phosphatase delta isoforms". J Biol Chem. 270 (12): 6722–8. doi:10.1074/jbc.270.12.6722. PMID 7896816.
4. Mizuno K, Hasegawa K, Katagiri T, Ogimoto M, Ichikawa T, Yakura H (Sep 1993). "MPTP delta, a putative murine homolog of HPTP delta, is expressed in specialized regions of the brain and in the B-cell lineage". Mol Cell Biol. 13 (9): 5513–23. doi:10.1128/MCB.13.9.5513. PMC 360267. PMID 8355697.
5. "Entrez Gene: PTPRD protein tyrosine phosphatase, receptor type, D".
6. Lei N, et al. (2010). "Autism Is Associated with Inherited Deletions in PTPRD and NCAM2". PAS 2010; Abstract 2320.1. Pediatric Academic Societies.
7. "OCD: New Genetic Marker Reported". 2014-06-07. Retrieved 2015-08-16.
8. Cancer Genome Atlas Network, Koboldt DC, Fulton RS, McLellan MD, Schmidt H, Kalicki-Veizer J, et al. (October 2012). "Comprehensive molecular portraits of human breast tumours". Nature. 490 (7418): 61–70. doi:10.1038/nature11412. PMC 3465532. PMID 23000897.
9. Wallace MJ, Fladd C, Batt J, Rotin D (May 1998). "The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma". Mol. Cell. Biol. 18 (5): 2608–16. doi:10.1128/MCB.18.5.2608. PMC 110640. PMID 9566880.
10. Pulido R, Serra-Pagès C, Tang M, Streuli M (Dec 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829.

Further reading

• Krueger NX, Streuli M, Saito H (1990). "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases". EMBO J. 9 (10): 3241–52. doi:10.1002/j.1460-2075.1990.tb07523.x. PMC 552056. PMID 2170109.
• Schaapveld RQ, van den Maagdenberg AM, Schepens JT, Weghuis DO, Geurts van Kessel A, Wieringa B, Hendriks WJ (1995). "The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization". Genomics. 27 (1): 124–30. doi:10.1006/geno.1995.1014. hdl:2066/21329. PMID 7665159.
• Pulido R, Serra-Pagès C, Tang M, Streuli M (1996). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829.
• Wagner J, Gordon LA, Heng HH, Tremblay ML, Olsen AS (1997). "Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3". Genomics. 38 (1): 76–8. doi:10.1006/geno.1996.0594. PMID 8954782.
• Wallace MJ, Fladd C, Batt J, Rotin D (1998). "The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma". Mol. Cell. Biol. 18 (5): 2608–16. doi:10.1128/MCB.18.5.2608. PMC 110640. PMID 9566880.
• Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153.
• Blanchetot C, den Hertog J (2000). "Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPs". J. Biol. Chem. 275 (17): 12446–52. doi:10.1074/jbc.275.17.12446. PMID 10777529.
• Blanchetot C, Tertoolen LG, Overvoorde J, den Hertog J (2003). "Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases". J. Biol. Chem. 277 (49): 47263–9. doi:10.1074/jbc.M205810200. PMID 12376545.
• Woodings JA, Sharp SJ, Machesky LM (2003). "MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta". Biochem. J. 371 (Pt 2): 463–71. doi:10.1042/BJ20021962. PMC 1223315. PMID 12570871.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Sato M, Takahashi K, Nagayama K, Arai Y, Ito N, Okada M, Minna JD, Yokota J, Kohno T (2005). "Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer". Genes Chromosomes Cancer. 44 (4): 405–14. doi:10.1002/gcc.20253. PMID 16114034. S2CID 25616464.
• Purdie KJ, Lambert SR, Teh MT, Chaplin T, Molloy G, Raghavan M, Kelsell DP, Leigh IM, Harwood CA, Proby CM, Young BD (2007). "Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis". Genes Chromosomes Cancer. 46 (7): 661–9. doi:10.1002/gcc.20447. PMC 2426828. PMID 17420988.