SSH3

Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene.[5][6]

SSH3
Identifiers
Aliases	SSH3, SSH3L, slingshot protein phosphatase 3
External IDs	OMIM: 606780 MGI: 2683546 HomoloGene: 32372 GeneCards: SSH3
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 67,303,478 bp[1] End 67,312,607 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 4,261,668 bp[2] End 4,269,180 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein tyrosine phosphatase activity • phosphatase activity • actin binding • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity Cellular component • cytoplasm • cytoskeleton • cell nucleus Biological process • regulation of lamellipodium assembly • regulation of axonogenesis • regulation of actin polymerization or depolymerization • protein dephosphorylation • peptidyl-tyrosine dephosphorylation • dephosphorylation • cell morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54961	245857
Ensembl	ENSG00000172830	ENSMUSG00000034616
UniProt	Q8TE77	Q8K330
RefSeq (mRNA)	NM_017857 NM_018276	NM_198113 NM_001356620 NM_001374687
RefSeq (protein)	NP_060327	NP_932781 NP_001343549
Location (UCSC)	Chr 11: 67.3 – 67.31 Mb	Chr 19: 4.26 – 4.27 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000172830 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034616 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (January 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. S2CID 5576208.
6. "Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)".

Further reading

• Kligys K, Claiborne JN, DeBiase PJ, Hopkinson SB, Wu Y, Mizuno K, Jones JC (November 2007). "The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes". The Journal of Biological Chemistry. 282 (44): 32520–8. doi:10.1074/jbc.M707041200. PMC 2754063. PMID 17848544.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, Sampath R, Bamburg JR, Bernard O (February 2005). "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". The EMBO Journal. 24 (3): 473–86. doi:10.1038/sj.emboj.7600543. PMC 548651. PMID 15660133.
• Ohta Y, Kousaka K, Nagata-Ohashi K, Ohashi K, Muramoto A, Shima Y, Niwa R, Uemura T, Mizuno K (October 2003). "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin". Genes to Cells. 8 (10): 811–24. doi:10.1046/j.1365-2443.2003.00678.x. PMID 14531860. S2CID 24247372.