Bamipine

Bamipine (trade name Soventol) is a pharmaceutical drug acting as an H₁ antihistamine with anticholinergic properties. It is used as an antipruritic ointment.[1] No oral use is known.[2]

Bamipine

Clinical data
Trade names	Soventol
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral?, topical
ATC code	D04AA15 (WHO) R06AX01 (WHO)
Identifiers
IUPAC name N-benzyl-1-methyl-N-phenyl-piperidin-4-amine
CAS Number	4945-47-5
PubChem CID	72075
ChemSpider	65061
UNII	Y6BHZ28O92
KEGG	D07197
ChEMBL	ChEMBL520400
CompTox Dashboard (EPA)	DTXSID5057751
ECHA InfoCard	100.023.261
Chemical and physical data
Formula	C19H24N2
Molar mass	280.415 g·mol^−1
3D model (JSmol)	Interactive image
SMILES N(c1ccccc1)(Cc2ccccc2)C3CCN(C)CC3
InChI InChI=1S/C19H24N2/c1-20-14-12-19(13-15-20)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17/h2-11,19H,12-16H2,1H3 Key:VZSXTYKGYWISGQ-UHFFFAOYSA-N
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Adverse effects

Side effects are typical of an old (first-generation) antihistamine: tiredness in adults, agitation in children, mydriasis (dilation of the pupils). These effects are rare when bamipine is applied topically as an ointment. Allergic and hypersensitivity reactions are also rare. Acute eczema can be worsened by bamipine ointment.[3]

Contraindications and interactions

No clinically relevant contraindications or interactions with other drugs are known.[3]

Pharmacology

Pharmacokinetics

When applied topically, the maximal effect is reached after 20 to 60 minutes and lasts up to 48 hours. Bamipine is not absorbed through intact skin in relevant doses.[3]

References

1. , M Pairet, MP Pieper, CJM Meade, "Pharmaceutical compositions containing tiotropium salts and antihistamines and their use", published 2001
2. International Drug Names: Bamipine.
3. Haberfeld, H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Soventol-Gel.