CD177

CD177 antigen is a protein that in humans is encoded by the CD177 gene.[5][6][7]

CD177
Identifiers
Aliases	CD177, HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1, CD177 molecule
External IDs	OMIM: 162860 MGI: 1916141 HomoloGene: 49628 GeneCards: CD177
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.31 Start 43,353,686 bp[1] End 43,363,172 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 24,743,983 bp[2] End 24,760,311 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • protease binding • integrin binding • calcium-dependent protein binding Cellular component • anchored component of membrane • extracellular exosome • membrane • specific granule membrane • cell membrane • secretory granule membrane • plasma membrane raft • tertiary granule membrane • extracellular region • lamellipodium • cell projection • membrane raft Biological process • blood coagulation • leukocyte migration • neutrophil degranulation • cell adhesion • leukocyte cell-cell adhesion • regulation of endocytosis • positive regulation of superoxide anion generation • protein localization to cell surface • positive regulation of neutrophil degranulation • cell-cell junction maintenance • neutrophil extravasation • cell-cell adhesion via plasma-membrane adhesion molecules • neutrophil migration • regulation of integrin-mediated signaling pathway • immune system process • innate immune system Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57126	68891
Ensembl	ENSG00000204936	ENSMUSG00000052212
UniProt	Q8N6Q3	Q8R2S8
RefSeq (mRNA)	NM_020406	NM_026862
RefSeq (protein)	NP_065139	NP_081138
Location (UCSC)	Chr 19: 43.35 – 43.36 Mb	Chr 7: 24.74 – 24.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971). [supplied by OMIM][7]

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000204936 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052212 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Temerinac S, Klippel S, Strunck E, Roder S, Lubbert M, Lange W, Azemar M, Meinhardt G, Schaefer HE, Pahl HL (May 2000). "Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera". Blood. 95 (8): 2569–76. doi:10.1182/blood.V95.8.2569. PMID 10753836.
6. Lalezari P, Murphy GB, Allen FH Jr (Jun 1971). "NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia". J Clin Invest. 50 (5): 1108–15. doi:10.1172/JCI106582. PMC 292033. PMID 5552408.
7. "Entrez Gene: CD177 CD177 molecule".

Further reading

• Stroncek D (2003). "Neutrophil-specific antigen HNA-2a (NB1, CD177): serology, biochemistry, and molecular biology". Vox Sang. 83 Suppl 1: 359–61. doi:10.1111/j.1423-0410.2002.tb05334.x. PMID 12617169. S2CID 36683379.
• Pahl HL (2003). "PRV-1 mRNA expression and other molecular markers in polycythemia rubra vera". Curr. Hematol. Rep. 2 (3): 231–6. PMID 12901344.
• Kralovics R, Skoda RC (2005). "Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders". Blood Rev. 19 (1): 1–13. doi:10.1016/j.blre.2004.02.002. PMID 15572213.
• Goldschmeding R, van Dalen CM, Faber N, et al. (1992). "Further characterization of the NB 1 antigen as a variably expressed 56-62 kD GPI-linked glycoprotein of plasma membranes and specific granules of neutrophils". Br. J. Haematol. 81 (3): 336–45. doi:10.1111/j.1365-2141.1992.tb08237.x. PMID 1382544. S2CID 11604830.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Stroncek DF, Herr GP, Plachta LB (1994). "Neutrophil-specific antigen NB1 inhibits neutrophil-endothelial cell interactions". J. Lab. Clin. Med. 123 (2): 247–55. PMID 8301201.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kissel K, Santoso S, Hofmann C, et al. (2001). "Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immune neutropenias and transfusion reactions". Eur. J. Immunol. 31 (5): 1301–9. doi:10.1002/1521-4141(200105)31:5<1301::AID-IMMU1301>3.0.CO;2-J. PMID 11465086.
• Bettinotti MP, Olsen A, Stroncek D (2002). "The use of bioinformatics to identify the genomic structure of the gene that encodes neutrophil antigen NB1, CD177". Clin. Immunol. 102 (2): 138–44. doi:10.1006/clim.2001.5154. PMID 11846455.
• Kissel K, Scheffler S, Kerowgan M, Bux J (2002). "Molecular basis of NB1 (HNA-2a, CD177) deficiency". Blood. 99 (11): 4231–3. doi:10.1182/blood.V99.11.4231. PMID 12010833.
• Klippel S, Strunck E, Busse CE, et al. (2002). "Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera". Blood. 100 (7): 2441–8. doi:10.1182/blood-2002-03-0949. PMID 12239154.
• Teofili L, Martini M, Luongo M, et al. (2002). "Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia". J. Clin. Oncol. 20 (20): 4249–54. doi:10.1200/JCO.2002.11.507. PMID 12377969.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Najfeld V, Fuchs S, Merando P, et al. (2003). "Fluorescence in situ hybridization analysis of the PRV-1 gene in polycythemia vera: implications for its role in diagnosis and pathogenesis". Exp. Hematol. 31 (2): 118–21. doi:10.1016/S0301-472X(02)01032-9. PMID 12591276.
• Wolff J, Brendel C, Fink L, et al. (2003). "Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms". Blood. 102 (2): 731–3. doi:10.1182/blood-2002-09-2831. PMID 12623849.
• Johansson P, Andréasson B, Safai-Kutti S, et al. (2003). "The presence of a significant association between elevated PRV-1 mRNA expression and low plasma erythropoietin concentration in essential thrombocythaemia". Eur. J. Haematol. 70 (6): 358–62. doi:10.1034/j.1600-0609.2003.00079.x. PMID 12756017. S2CID 13222207.

External links

• CD177+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CD177 genome location and CD177 gene details page in the UCSC Genome Browser.