LILRA2

Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the LILRA2 gene.[3][4][5]

LILRA2
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesLILRA2, CD85H, ILT1, LIR-7, LIR7, leukocyte immunoglobulin like receptor A2
External IDsOMIM: 604812 HomoloGene: 68534 GeneCards: LILRA2
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.42Start54,572,920 bp[1]
End54,590,287 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11027

n/a

Ensembl

ENSG00000239998
ENSG00000274000
ENSG00000275290
ENSG00000278634

n/a

UniProt

Q8N149

n/a

RefSeq (mRNA)

NM_001130917
NM_001290270
NM_001290271
NM_006866

n/a

RefSeq (protein)

NP_001124389
NP_001277199
NP_001277200
NP_006857

n/a

Location (UCSC)Chr 19: 54.57 – 54.59 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.[supplied by OMIM][5]

Function

LILRA2 senses microbially cleaved immunoglobulin to activate human myeloid cells.[6]

See also

References

  1. ENSG00000274000, ENSG00000275290, ENSG00000278634 GRCh38: Ensembl release 89: ENSG00000239998, ENSG00000274000, ENSG00000275290, ENSG00000278634 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806. S2CID 2212182.
  4. Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol. 159 (11): 5192–6. PMID 9548455.
  5. "Entrez Gene: LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2".
  6. Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nagai H, Nakamura Y, Katayama I, Colonna M, Arase H (Apr 2016). "LILRA2 is an innate immune sensor for microbially cleaved immunoglobulins". Nature Microbiology. 1 (6): 16054. doi:10.1038/NMICROBIOL.2016.54. PMID 27572839. S2CID 25500253.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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