CD83

CD83 (Cluster of Differentiation 83) is a human protein encoded by the CD83 gene.[4]

CD83
Identifiers
Aliases	CD83, BL11, HB15, CD83 molecule
External IDs	OMIM: 604534 MGI: 1328316 HomoloGene: 3121 GeneCards: CD83
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p23 Start 14,117,256 bp[1] End 14,136,918 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • external side of plasma membrane • membrane Biological process • regulation of cytokine production • defense response • positive regulation of CD4-positive, alpha-beta T cell differentiation • humoral immune response • response to organic cyclic compound • positive regulation of interleukin-2 production • negative regulation of interleukin-4 production • signal transduction • positive regulation of interleukin-10 production Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9308	12522
Ensembl	ENSG00000112149	ENSMUSG00000015396
UniProt	Q01151	O88324
RefSeq (mRNA)	NM_004233 NM_001040280 NM_001251901	NM_001289915 NM_009856
RefSeq (protein)	NP_001035370 NP_001238830 NP_004224	NP_001276844 NP_033986
Location (UCSC)	Chr 6: 14.12 – 14.14 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000112149 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: CD83 CD83 molecule".

Further reading

• Lechmann M, Berchtold S, Hauber J, Steinkasserer A (2002). "CD83 on dendritic cells: more than just a marker for maturation". Trends Immunol. 23 (6): 273–5. doi:10.1016/S1471-4906(02)02214-7. PMID 12072358.
• Zhou LJ, Schwarting R, Smith HM, Tedder TF (1992). "A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily". J. Immunol. 149 (2): 735–42. PMID 1378080.
• Zhou LJ, Tedder TF (1995). "Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily". J. Immunol. 154 (8): 3821–35. PMID 7706722.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Kozlow EJ, Wilson GL, Fox CH, Kehrl JH (1993). "Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes". Blood. 81 (2): 454–61. doi:10.1182/blood.V81.2.454.454. PMID 8422464.
• de la Fuente MA, Pizcueta P, Nadal M, Bosch J, Engel P (1997). "CD84 leukocyte antigen is a new member of the Ig superfamily". Blood. 90 (6): 2398–405. doi:10.1182/blood.V90.6.2398. PMID 9310491.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Olavesen MG, Bentley E, Mason RV, Stephens RJ, Ragoussis J (1998). "Fine mapping of 39 ESTs on human chromosome 6p23-p25". Genomics. 46 (2): 303–6. doi:10.1006/geno.1997.5032. PMID 9417921.
• Twist CJ, Beier DR, Disteche CM, Edelhoff S, Tedder TF (1998). "The mouse Cd83 gene: structure, domain organization, and chromosome localization". Immunogenetics. 48 (6): 383–93. doi:10.1007/s002510050449. PMID 9799334. S2CID 19869850.
• Berchtold S, Mühl-Zürbes P, Heufler C, Winklehner P, Schuler G, Steinkasserer A (1999). "Cloning, recombinant expression and biochemical characterization of the murine CD83 molecule which is specifically upregulated during dendritic cell maturation". FEBS Lett. 461 (3): 211–6. doi:10.1016/S0014-5793(99)01465-9. PMID 10567699. S2CID 28053654.
• Scholler N, Hayden-Ledbetter M, Hellström KE, Hellström I, Ledbetter JA (2001). "CD83 is a sialic acid-binding Ig-like lectin (Siglec) adhesion receptor that binds monocytes and a subset of activated CD8+ T cells". J. Immunol. 166 (6): 3865–72. doi:10.4049/jimmunol.166.6.3865. PMID 11238630.
• Fanales-Belasio E, Moretti S, Nappi F, Barillari G, Micheletti F, Cafaro A, Ensoli B (2002). "Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses" (PDF). J. Immunol. 168 (1): 197–206. doi:10.4049/jimmunol.168.1.197. PMID 11751963. S2CID 25473321.
• Berchtold S, Mühl-Zürbes P, Maczek E, Golka A, Schuler G, Steinkasserer A (2003). "Cloning and characterization of the promoter region of the human CD83 gene". Immunobiology. 205 (3): 231–46. doi:10.1078/0171-2985-00128. PMID 12182451.
• te Velde AA, van Kooyk Y, Braat H, Hommes DW, Dellemijn TA, Slors JF, van Deventer SJ, Vyth-Dreese FA (2003). "Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease". Eur. J. Immunol. 33 (1): 143–51. doi:10.1002/immu.200390017. PMID 12594843. S2CID 44959575.
• Dudziak D, Kieser A, Dirmeier U, Nimmerjahn F, Berchtold S, Steinkasserer A, Marschall G, Hammerschmidt W, Laux G, Bornkamm GW (2003). "Latent Membrane Protein 1 of Epstein-Barr Virus Induces CD83 by the NF-κB Signaling Pathway". J. Virol. 77 (15): 8290–8. doi:10.1128/JVI.77.15.8290-8298.2003. PMC 165234. PMID 12857898.
• Hock BD, Haring LF, Steinkasserer A, Taylor KG, Patton WN, McKenzie JL (2004). "The soluble form of CD83 is present at elevated levels in a number of hematological malignancies". Leuk. Res. 28 (3): 237–41. doi:10.1016/S0145-2126(03)00255-8. PMID 14687618.
• Sénéchal B, Boruchov AM, Reagan JL, Hart DN, Young JW (2004). "Infection of mature monocyte-derived dendritic cells with human cytomegalovirus inhibits stimulation of T-cell proliferation via the release of soluble CD83". Blood. 103 (11): 4207–15. doi:10.1182/blood-2003-12-4350. PMID 14962896.
• Cao W, Lee SH, Lu J (2005). "CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells". Biochem. J. 385 (Pt 1): 85–93. doi:10.1042/BJ20040741. PMC 1134676. PMID 15320871.

External links

• CD83+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CD83 genome location and CD83 gene details page in the UCSC Genome Browser.