CLEC10A

C-type lectin domain family 10 member A also known as CLEC10A is a protein that in humans is encoded by the CLEC10A gene.[5]

CLEC10A
Identifiers
Aliases	CLEC10A, CD301, CLECSF13, CLECSF14, HML, HML2, MGL, C-type lectin domain family 10 member A, C-type lectin domain containing 10A
External IDs	OMIM: 605999 MGI: 96975 HomoloGene: 7836 GeneCards: CLEC10A
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,074,537 bp[1] End 7,080,307 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 42.99 cM Start 70,156,197 bp[2] End 70,170,834 bp[2]
Gene ontology Molecular function • carbohydrate binding Cellular component • integral component of membrane • cell membrane • membrane Biological process • innate immune system • endocytosis • adaptive immune response • immune system process • stimulatory C-type lectin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10462	17312
Ensembl	ENSG00000132514	ENSMUSG00000000318
UniProt	Q8IUN9	P49300
RefSeq (mRNA)	NM_006344 NM_182906 NM_001330070	NM_001204252 NM_010796
RefSeq (protein)	NP_001316999 NP_006335 NP_878910	NP_001191181 NP_034926
Location (UCSC)	Chr 17: 7.07 – 7.08 Mb	Chr 11: 70.16 – 70.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000132514 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000318 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Suzuki N, Yamamoto K, Toyoshima S, Osawa T, Irimura T (January 1996). "Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen". J. Immunol. 156 (1): 128–35. PMID 8598452.
6. "Entrez Gene: CLEC10A C-type lectin domain family 10, member A".

External links

• Human CLEC10A genome location and CLEC10A gene details page in the UCSC Genome Browser.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• van Vliet SJ, Steeghs L, Bruijns SC, et al. (2009). Seifert HS (ed.). "Variation of Neisseria gonorrhoeae Lipooligosaccharide Directs Dendritic Cell–Induced T Helper Responses". PLOS Pathog. 5 (10): e1000625. doi:10.1371/journal.ppat.1000625. PMC 2757725. PMID 19834553.
• Iijima M, Tomita M, Morozumi S, et al. (2009). "Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP". Neurology. 73 (17): 1348–52. doi:10.1212/WNL.0b013e3181bd1139. PMID 19776380. S2CID 207116106.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.