CD3D

T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.[5]

CD3D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XIW
Identifiers
Aliases	CD3D, CD3-DELTA, IMD19, T3D, CD3d molecule
External IDs	OMIM: 186790 MGI: 88331 HomoloGene: 585 GeneCards: CD3D
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,338,954 bp[1] End 118,342,744 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 24.84 cM Start 44,981,786 bp[2] End 44,987,339 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • protein heterodimerization activity • transmembrane signaling receptor activity • protein homodimerization activity Cellular component • membrane • cytoplasm • alpha-beta T cell receptor complex • integral component of membrane • T cell receptor complex • clathrin-coated vesicle membrane • cell membrane • external side of plasma membrane Biological process • positive regulation of transcription from RNA polymerase II promoter • regulation of immune response • T cell receptor signaling pathway • T cell differentiation • positive thymic T cell selection • cell surface receptor signaling pathway • membrane organization • protein homooligomerization • adaptive immune response • immune system process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	915	12500
Ensembl	ENSG00000167286	ENSMUSG00000032094
UniProt	P04234	P04235
RefSeq (mRNA)	NM_001040651 NM_000732	NM_013487
RefSeq (protein)	NP_000723 NP_001035741	NP_038515
Location (UCSC)	Chr 11: 118.34 – 118.34 Mb	Chr 9: 44.98 – 44.99 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CD3D has been shown to interact with CD8A.[6]

See also

• CD3 (immunology)
• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000167286 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032094 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex)".
6. Doucey, Marie-Agnès; Goffin Laurence; Naeher Dieter; Michielin Olivier; Baumgärtner Petra; Guillaume Philippe; Palmer Ed; Luescher Immanuel F (Jan 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. United States. 278 (5): 3257–64. doi:10.1074/jbc.M208119200. ISSN 0021-9258. PMID 12215456.

Further reading

• Balk SP, Polischuk JE, Probert C, et al. (1996). "Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain". Int. Immunol. 7 (8): 1237–41. doi:10.1093/intimm/7.8.1237. PMID 7495730.
• Li CJ (2007). "Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference". J. Cell. Physiol. 209 (3): 695–700. doi:10.1002/jcp.20817. PMID 17001685. S2CID 37846031.
• Phillips JH, Hori T, Nagler A, et al. (1992). "Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon, delta proteins". J. Exp. Med. 175 (4): 1055–66. doi:10.1084/jem.175.4.1055. PMC 2119193. PMID 1372642.
• Luzzati AL, Giacomini E, Giordani L, et al. (1992). "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope". Immunol. Lett. 33 (3): 307–14. doi:10.1016/0165-2478(92)90078-3. PMID 1385321.
• Alarcón B, Ley SC, Sánchez-Madrid F, et al. (1991). "The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes". EMBO J. 10 (4): 903–12. doi:10.1002/j.1460-2075.1991.tb08023.x. PMC 452733. PMID 1826255.
• Hori T, de Waal Malefyt R, Duncan BW, et al. (1991). "Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3". Int. Immunol. 3 (4): 353–7. doi:10.1093/intimm/3.4.353. PMID 1831653.
• Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx". Cell. Immunol. 137 (1): 1–13. doi:10.1016/0008-8749(91)90051-C. PMID 1832084.
• Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
• Luzzati AL, Pugliese O, Giacomini E, et al. (1990). "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV". Folia Biol. (Praha). 36 (1): 71–7. PMID 2111780.
• Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299–305. doi:10.1002/eji.1830200211. PMID 2138083. S2CID 2180901.
• Alexander D, Goris J, Marais R, et al. (1989). "Dephosphorylation of the human T lymphocyte CD3 antigen". Eur. J. Biochem. 181 (1): 55–65. doi:10.1111/j.1432-1033.1989.tb14693.x. PMID 2540970.
• Tunnacliffe A, Buluwela L, Rabbitts TH (1988). "Physical linkage of three CD3 genes on human chromosome 11". EMBO J. 6 (10): 2953–7. doi:10.1002/j.1460-2075.1987.tb02600.x. PMC 553731. PMID 2826124.
• van den Elsen P, Shepley BA, Cho M, Terhorst C (1985). "Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein". Nature. 314 (6011): 542–4. Bibcode:1985Natur.314..542V. doi:10.1038/314542a0. PMID 2859526. S2CID 4321989.
• van den Elsen P, Georgopoulos K, Shepley BA, et al. (1986). "Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex". Proc. Natl. Acad. Sci. U.S.A. 83 (9): 2944–8. Bibcode:1986PNAS...83.2944V. doi:10.1073/pnas.83.9.2944. PMC 323423. PMID 2939461.
• Gold DP, Clevers H, Alarcon B, et al. (1987). "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7649–53. Bibcode:1987PNAS...84.7649G. doi:10.1073/pnas.84.21.7649. PMC 299357. PMID 3478717.
• Tunnacliffe A, Sims JE, Rabbitts TH (1986). "T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells". EMBO J. 5 (6): 1245–52. doi:10.1002/j.1460-2075.1986.tb04353.x. PMC 1166934. PMID 3488209.
• van den Elsen P, Shepley BA, Borst J, et al. (1985). "Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex". Nature. 312 (5993): 413–8. Bibcode:1984Natur.312..413V. doi:10.1038/312413a0. PMID 6095101. S2CID 4347265.
• Oravecz T, Norcross MA (1994). "Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120". AIDS Res. Hum. Retroviruses. 9 (10): 945–55. doi:10.1089/aid.1993.9.945. PMID 7506554.
• Luzzati AL, Giacomini E, Giordani L, et al. (1994). "An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex". Cell. Immunol. 156 (2): 286–95. doi:10.1006/cimm.1994.1175. PMID 7517794.

External links

• Human CD3D genome location and CD3D gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P04234 (T-cell surface glycoprotein CD3 delta chain) at the PDBe-KB.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human T-cell surface glycoprotein CD3 delta chain (CD3D)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.