MYH4

Myosin-4 also known as myosin, heavy chain 4 is a protein which in humans is encoded by the MYH4 gene.[5]

MYH4
Identifiers
Aliases	MYH4, MYH2B, MyHC-2B, MyHC-IIb, myosin, heavy chain 4, skeletal muscle, myosin heavy chain 4
External IDs	OMIM: 160742 MGI: 1339713 HomoloGene: 123880 GeneCards: MYH4
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 10,443,290 bp[1] End 10,469,559 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 40.59 cM Start 67,238,029 bp[2] End 67,260,446 bp[2]
Gene ontology Molecular function • nucleotide binding • actin binding • microfilament motor activity • double-stranded RNA binding • ATPase activity • cellular motor activity • ATP binding • calmodulin binding • actin filament binding • microtubule motor activity • microtubule binding Cellular component • cytoplasm • myosin filament • muscle myosin complex • myofibril • sarcomere • myosin complex Biological process • ATP metabolic process • muscle contraction • actin filament-based movement • muscle filament sliding • microtubule-based movement • response to activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4622	17884
Ensembl	ENSG00000264424	ENSMUSG00000057003
UniProt	Q9Y623	Q5SX39
RefSeq (mRNA)	NM_017533	NM_010855
RefSeq (protein)	NP_060003	NP_034985
Location (UCSC)	Chr 17: 10.44 – 10.47 Mb	Chr 11: 67.24 – 67.26 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

MYH4 is a gene that encodes a sarcomeric myosin.

References

1. GRCh38: Ensembl release 89: ENSG00000264424 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057003 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Edwards YH, Parkar M, Povey S, West LF, Parrington JM, Solomon E (May 1985). "Human myosin heavy chain genes assigned to chromosome 17 using a human cDNA clone as probe". Ann. Hum. Genet. 49 (Pt 2): 101–9. doi:10.1111/j.1469-1809.1985.tb01681.x. PMID 3000272. S2CID 7405468.

Further reading

• Sant'ana Pereira JA, Wessels A, Nijtmans L, et al. (1995). "New method for the accurate characterization of single human skeletal muscle fibres demonstrates a relation between mATPase and MyHC expression in pure and hybrid fibre types". J. Muscle Res. Cell. Motil. 16 (1): 21–34. doi:10.1007/BF00125307. PMID 7751402. S2CID 20954615.
• Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619.
• Barton PJ, Buckingham ME (1985). "The myosin alkali light chain proteins and their genes". Biochem. J. 231 (2): 249–61. doi:10.1042/bj2310249. PMC 1152739. PMID 3904738.
• Horton MJ, Brandon CA, Morris TJ, et al. (2001). "Abundant expression of myosin heavy-chain IIB RNA in a subset of human masseter muscle fibres". Arch. Oral Biol. 46 (11): 1039–50. doi:10.1016/S0003-9969(01)00066-8. PMC 3848045. PMID 11543711.
• Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
• Larsson L, Moss RL (1993). "Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles". J. Physiol. 472: 595–614. doi:10.1113/jphysiol.1993.sp019964. PMC 1160504. PMID 8145163.
• Li ZH, Spektor A, Varlamova O, Bresnick AR (2003). "Mts1 regulates the assembly of nonmuscle myosin-IIA". Biochemistry. 42 (48): 14258–66. doi:10.1021/bi0354379. PMID 14640694.
• Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.
• Ford HL, Silver DL, Kachar B, et al. (1997). "Effect of Mts1 on the structure and activity of nonmuscle myosin II". Biochemistry. 36 (51): 16321–7. doi:10.1021/bi971182l. PMID 9405067.
• Soussi-Yanicostas N, Whalen RG, Petit C (1993). "Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome". Hum. Mol. Genet. 2 (5): 563–9. doi:10.1093/hmg/2.5.563. PMID 8518795.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.