CLCA2

Chloride channel accessory 2 is a protein that in humans is encoded by the CLCA2 gene.[5]

CLCA2
Identifiers
Aliases	CLCA2, CACC, CACC3, CLCRG2, CaCC-3, chloride channel accessory 2
External IDs	OMIM: 604003 MGI: 2139758 HomoloGene: 4765 GeneCards: CLCA2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 86,424,171 bp[1] End 86,456,553 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H2 Start 145,070,263 bp[2] End 145,099,443 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • peptidase activity • ligand-gated ion channel activity • hydrolase activity • metallopeptidase activity • chloride channel activity • metalloendopeptidase activity • intracellular calcium activated chloride channel activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane • extracellular region • cell junction • basal plasma membrane • cell nucleus • cytosol • cell membrane • not the membrane Biological process • chloride transmembrane transport • ion transport • proteolysis • cell adhesion • chloride transport • ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9635	229933
Ensembl	ENSG00000137975	ENSMUSG00000036960
UniProt	Q9UQC9	Q8BG22
RefSeq (mRNA)	NM_006536	NM_178697
RefSeq (protein)	NP_006527	NP_848812
Location (UCSC)	Chr 1: 86.42 – 86.46 Mb	Chr 3: 145.07 – 145.1 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.[5] Protein structure prediction methods suggest the N-terminal region of CLCA2 protein is a zinc metalloprotease.[6]

See also

• Chloride channel

References

1. GRCh38: Ensembl release 89: ENSG00000137975 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036960 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CLCA2 chloride channel, calcium activated, family member 2".
6. Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. S2CID 40041491.

Further reading

• Pauli BU, Abdel-Ghany M, Cheng HC, et al. (2001). "Molecular characteristics and functional diversity of CLCA family members". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. doi:10.1046/j.1440-1681.2000.03358.x. PMID 11071307. S2CID 28762005.
• Gruber AD, Schreur KD, Ji HL, et al. (1999). "Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland". Am. J. Physiol. 276 (6 Pt 1): C1261–70. doi:10.1152/ajpcell.1999.276.6.C1261. PMID 10362588.
• Agnel M, Vermat T, Culouscou JM (1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792. S2CID 82094058.
• Gruber AD, Pauli BU (1999). "Tumorigenicity of human breast cancer is associated with loss of the Ca²⁺-activated chloride channel CLCA2". Cancer Res. 59 (21): 5488–91. PMID 10554024.
• Gruber AD, Pauli BU (1999). "Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31)". Genome. 42 (5): 1030–2. doi:10.1139/gen-42-5-1030. PMID 10584316.
• Liu QH, Williams DA, McManus C, et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS...97.4832L. doi:10.1073/pnas.090521697. PMC 18318. PMID 10758170.
• Koegel H, Alzheimer C (2001). "Expression and biological significance of Ca²⁺-activated ion channels in human keratinocytes". FASEB J. 15 (1): 145–154. doi:10.1096/fj.00-0055com. PMID 11149902. S2CID 7187615.
• Itoh R, Kawamoto S, Miyamoto Y, et al. (2001). "Isolation and characterization of a Ca²⁺-activated chloride channel from human corneal epithelium". Curr. Eye Res. 21 (6): 918–25. doi:10.1076/ceyr.21.6.918.6983. PMID 11262615. S2CID 20814432.
• Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU (2001). "The breast cancer beta 4 integrin and endothelial human CLCA2 mediate lung metastasis". J. Biol. Chem. 276 (27): 25438–46. doi:10.1074/jbc.M100478200. PMID 11320086.
• Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU (2002). "Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth". J. Biol. Chem. 277 (37): 34391–400. doi:10.1074/jbc.M205307200. PMID 12110680.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mall M, Gonska T, Thomas J, et al. (2003). "Modulation of Ca²⁺-activated Cl⁻ secretion by basolateral K⁺ channels in human normal and cystic fibrosis airway epithelia". Pediatr. Res. 53 (4): 608–18. doi:10.1203/01.PDR.0000057204.51420.DC. PMID 12612194.
• Abdel-Ghany M, Cheng HC, Elble RC, et al. (2004). "The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis". J. Biol. Chem. 278 (49): 49406–16. doi:10.1074/jbc.M309086200. PMID 14512419.
• Connon CJ, Kawasaki S, Yamasaki K, et al. (2005). "The quantification of hCLCA2 and colocalisation with integrin beta4 in stratified human epithelia". Acta Histochem. 106 (6): 421–5. doi:10.1016/j.acthis.2004.08.003. PMID 15707651.
• Connon CJ, Kawasaki S, Liles M, et al. (2006). "Gene expression and immunolocalisation of a calcium-activated chloride channel during the stratification of cultivated and developing corneal epithelium". Cell Tissue Res. 323 (1): 177–82. doi:10.1007/s00441-005-0059-2. PMID 16158324. S2CID 20539445.
• Elble RC, Walia V, Cheng HC, et al. (2006). "The putative chloride channel hCLCA2 has a single C-terminal transmembrane segment". J. Biol. Chem. 281 (40): 29448–54. doi:10.1074/jbc.M605919200. PMID 16873362.

External links

• CLCN1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CLCA2 genome location and CLCA2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.