CLIC3

Chloride intracellular channel protein 3 is a protein that in humans is encoded by the CLIC3 gene.[5] This protein is a chloride channel.[5]

CLIC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FY7, 3KJY
Identifiers
Aliases	CLIC3, chloride intracellular channel 3
External IDs	OMIM: 606533 MGI: 1916704 HomoloGene: 3432 GeneCards: CLIC3
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 136,994,608 bp[1] End 136,996,568 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 25,456,838 bp[2] End 25,458,776 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • voltage-gated ion channel activity • chloride channel activity • glutathione transferase activity Cellular component • cytoplasm • integral component of membrane • extracellular exosome • membrane • cell nucleus • chloride channel complex • nuclear body Biological process • regulation of ion transmembrane transport • chloride transport • ion transport • signal transduction • chloride transmembrane transport • glutathione metabolic process • transport • ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9022	69454
Ensembl	ENSG00000169583	ENSMUSG00000015093
UniProt	O95833	Q9D7P7
RefSeq (mRNA)	NM_004669	NM_027085
RefSeq (protein)	NP_004660	NP_081361
Location (UCSC)	Chr 9: 136.99 – 137 Mb	Chr 2: 25.46 – 25.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Chloride channel

References

1. GRCh38: Ensembl release 89: ENSG00000169583 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015093 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Qian Z, Okuhara D, Abe MK, Rosner MR (Feb 1999). "Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel". J Biol Chem. 274 (3): 1621–7. doi:10.1074/jbc.274.3.1621. PMID 9880541.

Further reading

• Singh H (2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters. 584 (10): 2112–21. doi:10.1016/j.febslet.2010.03.013. PMID 20226783. S2CID 21056278.
• Valenzuela SM, Martin DK, Por SB, et al. (1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei". J. Biol. Chem. 272 (19): 12575–82. doi:10.1074/jbc.272.19.12575. PMID 9139710.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suginta W, Karoulias N, Aitken A, Ashley RH (2001). "Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms". Biochem. J. 359 (Pt 1): 55–64. doi:10.1042/0264-6021:3590055. PMC 1222121. PMID 11563969.
• Money TT, King RG, Wong MH, et al. (2007). "Expression and cellular localisation of chloride intracellular channel 3 in human placenta and fetal membranes". Placenta. 28 (5–6): 429–36. doi:10.1016/j.placenta.2006.08.002. PMID 17027078.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• CLIC3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CLIC3 genome location and CLIC3 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: O95833 (Human Chloride intracellular channel protein 3 (CLIC3)) at the PDBe-KB.