KCNK16

Potassium channel subfamily K member 16 is a protein that in humans is encoded by the KCNK16 gene.[4][5] The protein encoded by this gene, K_2P16.1, is a potassium channel containing two pore-forming P domains.[4][5]

KCNK16
Identifiers
Aliases	KCNK16, K2p16.1, TALK-1, TALK1, potassium two pore domain channel subfamily K member 16
External IDs	OMIM: 607369 MGI: 1921821 HomoloGene: 75328 GeneCards: KCNK16
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.2 Start 39,314,698 bp[1] End 39,322,968 bp[1]
Gene ontology Molecular function • GO:0001948 protein binding • voltage-gated ion channel activity • potassium channel activity • potassium ion leak channel activity Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane Biological process • potassium ion transport • regulation of ion transmembrane transport • ion transport • potassium ion transmembrane transport • stabilization of membrane potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83795	74571
Ensembl	ENSG00000095981	ENSMUSG00000023387
UniProt	Q96T55	G5E845
RefSeq (mRNA)	NM_001135105 NM_001135106 NM_001135107 NM_032115 NM_001363784	NM_029006
RefSeq (protein)	NP_001128577 NP_001128578 NP_001128579 NP_115491 NP_001350713	NP_083282
Location (UCSC)	Chr 6: 39.31 – 39.32 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tandem pore domain potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000095981 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F (Mar 2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem Biophys Res Commun. 282 (1): 249–56. doi:10.1006/bbrc.2001.4562. PMID 11263999.
5. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

Further reading

• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
• Han J, Kang D, Kim D (2003). "Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1". Am. J. Physiol., Cell Physiol. 285 (3): C529–38. doi:10.1152/ajpcell.00601.2002. PMID 12724142.
• Gierten J, Ficker E, Bloehs R, et al. (2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein". Br. J. Pharmacol. 154 (8): 1680–90. doi:10.1038/bjp.2008.213. PMC 2518462. PMID 18516069.

External links

• KCNK16+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)