Cyclic nucleotide-gated channel alpha 4

Cyclic nucleotide-gated cation channel alpha-4 is a protein that in humans is encoded by the CNGA4 gene.[5][6][7]

CNGA4
Identifiers
Aliases	CNGA4, CNCA2, CNG-4, CNG4, CNG5, CNGB2, OCNC2, OCNCBETA, OCNCb, Cyclic nucleotide-gated channel alpha 4, cyclic nucleotide gated channel alpha 4, cyclic nucleotide gated channel subunit alpha 4
External IDs	OMIM: 609472 MGI: 2664099 HomoloGene: 13579 GeneCards: CNGA4
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 6,234,765 bp[1] End 6,244,479 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 105,404,568 bp[2] End 105,408,742 bp[2]
Gene ontology Molecular function • nucleotide binding • cAMP binding • voltage-gated potassium channel activity • ion channel activity • intracellular cAMP activated cation channel activity • intracellular cGMP activated cation channel activity • cGMP binding Cellular component • Golgi-associated vesicle membrane • integral component of membrane • Golgi membrane • membrane • ciliary membrane • integral component of plasma membrane Biological process • transmembrane transport • response to stimulus • sensory perception of smell • ion transport • ion transmembrane transport • regulation of membrane potential • potassium ion transmembrane transport • cation transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1262	233649
Ensembl	ENSG00000132259	ENSMUSG00000030897
UniProt	Q8IV77	Q3UW12
RefSeq (mRNA)	NM_001037329	NM_001033317
RefSeq (protein)	NP_001032406	NP_001028489
Location (UCSC)	Chr 11: 6.23 – 6.24 Mb	Chr 7: 105.4 – 105.41 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001).[supplied by OMIM][7]

See also

• Cyclic nucleotide-gated ion channel

References

1. GRCh38: Ensembl release 89: ENSG00000132259 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030897 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bradley J, Frings S, Yau KW, Reed R (Dec 2001). "Nomenclature for Ion channel Subunits". Science. 294 (5549): 2095–6. doi:10.1126/science.294.5549.2095. PMC 2901924. PMID 11764791.
6. Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.
7. "Entrez Gene: CNGA4 cyclic nucleotide gated channel alpha 4".

Further reading

• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kelliher KR, Ziesmann J, Munger SD, et al. (2003). "Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4299–304. doi:10.1073/pnas.0736071100. PMC 153087. PMID 12649326.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Munger SD, Lane AP, Zhong H, et al. (2002). "Central Role of the CNGA4 Channel Subunit in Ca2+-Calmodulin–Dependent Odor Adaptation". Science. 294 (5549): 2172–5. doi:10.1126/science.1063224. PMC 2885906. PMID 11739959.
• Sautter A, Zong X, Hofmann F, Biel M (1998). "An isoform of the rod photoreceptor cyclic nucleotide-gated channel β subunit expressed in olfactory neurons". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4696–701. doi:10.1073/pnas.95.8.4696. PMC 22553. PMID 9539801.

External links

• CNGA4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.