KCNK17

Potassium channel subfamily K member 17 is a protein that in humans is encoded by the KCNK17 gene.[3][4]

KCNK17
Identifiers
Aliases	KCNK17, K2p17.1, TALK-2, TALK2, TASK-4, TASK4, potassium two pore domain channel subfamily K member 17
External IDs	OMIM: 607370 HomoloGene: 88928 GeneCards: KCNK17
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.2 Start 39,299,001 bp[1] End 39,314,461 bp[1]
Gene ontology Molecular function • voltage-gated ion channel activity • potassium channel activity • potassium ion leak channel activity Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane Biological process • potassium ion transport • regulation of ion transmembrane transport • ion transport • potassium ion transmembrane transport • stabilization of membrane potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	89822	n/a
Ensembl	ENSG00000124780	n/a
UniProt	Q96T54	n/a
RefSeq (mRNA)	NM_001135111 NM_031460	n/a
RefSeq (protein)	NP_001128583 NP_113648	n/a
Location (UCSC)	Chr 6: 39.3 – 39.31 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene encodes K_2P17.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel, primarily expressed in the pancreas, is activated at alkaline pH.[4]

See also

• Tandem pore domain potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000124780 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
4. "Entrez Gene: KCNK17 potassium channel, subfamily K, member 17".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Girard C, Duprat F, Terrenoire C, et al. (2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem. Biophys. Res. Commun. 282 (1): 249–56. doi:10.1006/bbrc.2001.4562. PMID 11263999.
• Decher N, Maier M, Dittrich W, et al. (2001). "Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family". FEBS Lett. 492 (1–2): 84–9. doi:10.1016/S0014-5793(01)02222-0. PMID 11248242. S2CID 23620127.

External links

• KCNK17+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.