Cyclic nucleotide-gated channel alpha 2

Cyclic nucleotide gated channel alpha 2, also known as CNGA2, is a human gene encoding an ion channel protein.[5]

CNGA2
Identifiers
Aliases	CNGA2, CNCA, CNCA1, CNG2, OCNC1, OCNCALPHA, OCNCa, Cyclic nucleotide-gated channel alpha 2, cyclic nucleotide gated channel alpha 2, cyclic nucleotide gated channel subunit alpha 2
External IDs	OMIM: 300338 MGI: 108040 HomoloGene: 32022 GeneCards: CNGA2
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 151,738,451 bp[1] End 151,745,304 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 71,991,849 bp[2] End 72,010,218 bp[2]
Gene ontology Molecular function • nucleotide binding • cAMP binding • calmodulin binding • ion channel activity • voltage-gated potassium channel activity • intracellular cAMP activated cation channel activity • intracellular cGMP activated cation channel activity • cGMP binding Cellular component • integral component of membrane • membrane • Golgi membrane • ciliary membrane • Golgi-associated vesicle membrane • integral component of plasma membrane Biological process • response to stimulus • regulation of membrane potential • ion transport • sensory perception of smell • ion transmembrane transport • transmembrane transport • potassium ion transmembrane transport • cation transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1260	12789
Ensembl	ENSG00000183862	ENSMUSG00000005864
UniProt	Q16280	Q62398
RefSeq (mRNA)	NM_005140	NM_007724
RefSeq (protein)	NP_005131	NP_031750
Location (UCSC)	Chr X: 151.74 – 151.75 Mb	Chr X: 71.99 – 72.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Cyclic nucleotide-gated ion channel

References

1. GRCh38: Ensembl release 89: ENSG00000183862 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005864 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CNGA2 cyclic nucleotide gated channel alpha 2".

Further reading

• Trudeau MC, Zagotta WN (2003). "Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels". J. Biol. Chem. 278 (21): 18705–8. doi:10.1074/jbc.R300001200. PMID 12626507.
• Hofmann F, Biel M, Kaupp UB (2006). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol. Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.
• Distler M, Biel M, Flockerzi V, Hofmann F (1995). "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells". Neuropharmacology. 33 (11): 1275–82. doi:10.1016/0028-3908(94)90027-2. PMID 7532814.
• Finn JT, Krautwurst D, Schroeder JE, et al. (1998). "Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human". Biophys. J. 74 (3): 1333–45. Bibcode:1998BpJ....74.1333F. doi:10.1016/S0006-3495(98)77846-4. PMC 1299480. PMID 9512030.
• Sautter A, Zong X, Hofmann F, Biel M (1998). "An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4696–701. Bibcode:1998PNAS...95.4696S. doi:10.1073/pnas.95.8.4696. PMC 22553. PMID 9539801.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yoo D, Flagg TP, Olsen O, et al. (2004). "Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactions". J. Biol. Chem. 279 (8): 6863–73. doi:10.1074/jbc.M311599200. PMID 14604981.
• Cheng KT, Chan FL, Huang Y, et al. (2004). "Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues". Histochem. Cell Biol. 120 (6): 475–81. doi:10.1007/s00418-003-0596-2. PMID 14618336.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Qu W, Moorhouse AJ, Chandra M, et al. (2006). "A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel". J. Gen. Physiol. 127 (4): 375–89. doi:10.1085/jgp.200509378. PMC 2151509. PMID 16533895.

External links

• CNGA2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.