CLIC4

Chloride intracellular channel 4, also known as CLIC4, is a eukaryotic gene.[5]

CLIC4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLIC4, CLIC4L, H1, MTCLIC, huH1, p64H1, chloride intracellular channel 4
External IDsOMIM: 606536 MGI: 1352754 HomoloGene: 8490 GeneCards: CLIC4
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p36.11Start24,745,382 bp[1]
End24,844,321 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

25932

29876

Ensembl

ENSG00000169504

ENSMUSG00000037242

UniProt

Q9Y696

Q9QYB1

RefSeq (mRNA)

NM_013943

NM_013885

RefSeq (protein)

NP_039234

NP_038913

Location (UCSC)Chr 1: 24.75 – 24.84 MbChr 4: 135.21 – 135.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits an intracellular vesicular pattern in PANC-1 cells (pancreatic cancer cells).[5]

Binding partners

CLIC4 binds to dynamin I, α-tubulin, β-actin, creatine kinase and two 14-3-3 isoforms.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000169504 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037242 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CLIC4 chloride intracellular channel 4".
  6. Suginta W, Karoulias N, Aitken A, Ashley RH (October 2001). "Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms". Biochem. J. 359 (Pt1): 55–64. doi:10.1042/0264-6021:3590055. PMC 1222121. PMID 11563969.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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