KCNK5

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.[5][6][7]

KCNK5
Identifiers
Aliases	KCNK5, K2p5.1, TASK-2, TASK2, KCNK5b, potassium two pore domain channel subfamily K member 5
External IDs	OMIM: 603493 MGI: 1336175 HomoloGene: 2773 GeneCards: KCNK5
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.2 Start 39,188,971 bp[1] End 39,229,475 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 20,140,057 bp[2] End 20,181,809 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • voltage-gated potassium channel activity • potassium channel activity • voltage-gated ion channel activity • potassium ion leak channel activity Cellular component • integral component of membrane • integral component of plasma membrane • membrane Biological process • potassium ion transport • regulation of ion transmembrane transport • excretion • ion transport • potassium ion transmembrane transport • stabilization of membrane potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8645	16529
Ensembl	ENSG00000164626	ENSMUSG00000023243
UniProt	O95279	Q9JK62
RefSeq (mRNA)	NM_003740	NM_021542
RefSeq (protein)	NP_003731	NP_067517
Location (UCSC)	Chr 6: 39.19 – 39.23 Mb	Chr 14: 20.14 – 20.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes K_2P5.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport.[7]

See also

• Tandem pore domain potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000164626 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023243 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M (Dec 1998). "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney". J Biol Chem. 273 (47): 30863–9. doi:10.1074/jbc.273.47.30863. PMID 9812978.
6. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
7. "Entrez Gene: KCNK5 potassium channel, subfamily K, member 5".

Further reading

• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Gray AT, Zhao BB, Kindler CH, et al. (2000). "Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5". Anesthesiology. 92 (6): 1722–30. doi:10.1097/00000542-200006000-00032. PMID 10839924. S2CID 45487917.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Morton MJ, O'Connell AD, Sivaprasadarao A, Hunter M (2003). "Determinants of pH sensing in the two-pore domain K(+) channels TASK-1 and -2". Pflügers Arch. 445 (5): 577–83. doi:10.1007/s00424-002-0901-2. PMID 12634929. S2CID 6338907.
• Niemeyer MI, Cid LP, Valenzuela X, et al. (2004). "Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity". Mol. Membr. Biol. 20 (2): 185–91. doi:10.1080/0968768031000084181. hdl:10533/174402. PMID 12851074. S2CID 36255147.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Rusznák Z, Pocsai K, Kovács I, et al. (2004). "Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum". Cell. Mol. Life Sci. 61 (12): 1532–42. doi:10.1007/s00018-004-4082-3. PMID 15197476. S2CID 11439105.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• KCNK5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.