Brain-specific angiogenesis inhibitor 2

Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene.[5][6] It is a member of the adhesion-GPCR family of receptors.[7]

ADGRB2
Identifiers
Aliases	ADGRB2, BAI2, adhesion G protein-coupled receptor B2
External IDs	OMIM: 602683 MGI: 2451244 HomoloGene: 1288 GeneCards: ADGRB2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.2 Start 31,727,117 bp[1] End 31,764,893 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 129,984,870 bp[2] End 130,022,633 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transmembrane signaling receptor activity • signal transducer activity • G-protein coupled receptor activity • GO:0001948 protein binding Cellular component • integral component of membrane • membrane • cell membrane • centrosome • integral component of plasma membrane Biological process • negative regulation of angiogenesis • cell surface receptor signaling pathway • peripheral nervous system development • signal transduction • positive regulation of synapse assembly • G-protein coupled receptor signaling pathway • calcineurin-NFAT signaling cascade • adenylate cyclase-activating G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	576	230775
Ensembl	ENSG00000121753	ENSMUSG00000028782
UniProt	O60241	Q8CGM1
RefSeq (mRNA)	NM_001294335 NM_001294336 NM_001364857	NM_001199696 NM_001290714 NM_001290715 NM_173071 NM_001377056 NM_001377057 NM_001377058
RefSeq (protein)	NP_001281264 NP_001281265 NP_001351786	NP_001186625 NP_001277643 NP_001277644 NP_775094 NP_001363985 NP_001363986 NP_001363987
Location (UCSC)	Chr 1: 31.73 – 31.76 Mb	Chr 4: 129.98 – 130.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000121753 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028782 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet. 79 (1–2): 103–8. doi:10.1159/000134693. PMID 9533023.
6. "Entrez Gene: BAI2 brain-specific angiogenesis inhibitor 2".
7. Stacey, edited by Simon Yona, Martin (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 9781441979124.CS1 maint: extra text: authors list (link)

External links

• Human ADGRB2 genome location and ADGRB2 gene details page in the UCSC Genome Browser.

Further reading

• Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". J. Biol. Chem. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.
• Kee HJ, Koh JT, Kim MY, et al. (2002). "Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis". J. Cereb. Blood Flow Metab. 22 (9): 1054–67. doi:10.1097/00004647-200209000-00003. PMID 12218411.
• Petersen HH, Hilpert J, Militz D, et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell Sci. 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. PMID 12508107.
• Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell. Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
• Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochem. Biophys. Res. Commun. 313 (3): 654–65. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.