TAAR6

Trace amine associated receptor 6, also known as TAAR6, is a protein which in humans is encoded by the TAAR6 gene.[5][6]

TAAR6
Identifiers
Aliases	TAAR6, TA4, TAR4, TAR6, TRAR4, taR-4, taR-6, trace amine associated receptor 6
External IDs	OMIM: 608923 MGI: 2685074 HomoloGene: 27874 GeneCards: TAAR6
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.2 Start 132,570,322 bp[1] End 132,571,359 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A4 Start 23,984,609 bp[2] End 23,985,646 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • trace-amine receptor activity • G-protein coupled receptor activity • signal transducer activity Cellular component • cell membrane • membrane • integral component of membrane Biological process • G-protein coupled receptor signaling pathway • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	319100	215855
Ensembl	ENSG00000146383	ENSMUSG00000045111
UniProt	Q96RI8	Q5QD13
RefSeq (mRNA)	NM_175067	NM_001010828
RefSeq (protein)	NP_778237	NP_001010828
Location (UCSC)	Chr 6: 132.57 – 132.57 Mb	Chr 10: 23.98 – 23.99 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

TAAR6 belongs to the trace amine-associated receptor family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines like dopamine, norepinephrine, serotonin, and histamine. Trace amines were thought to be 'false transmitters' that displace classic biogenic amines from their storage and act on transporters in a fashion similar to the amphetamines, but the identification of brain receptors specific to trace amines indicates that they also have effects of their own.[7][8]

Computational modeling suggests TAAR6 can bind to the foul smelling compounds produced by rotting flesh, putrescine and cadaverine.[9]

TAAR6 knockout mice have some differences in behaviour, so this gene can have some functions in CNS.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000146383 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045111 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, et al. (July 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proceedings of the National Academy of Sciences of the United States of America. 98 (16): 8966–71. doi:10.1073/pnas.151105198. PMC 55357. PMID 11459929.
6. Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
7. Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, et al. (October 2004). "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia". American Journal of Human Genetics. 75 (4): 624–38. doi:10.1086/424887. PMC 1182049. PMID 15329799.
8. "Entrez Gene: TAAR6 trace amine associated receptor 6".
9. Izquierdo C, Gómez-Tamayo JC, Nebel JC, Pardo L, Gonzalez A (January 2018). "Identifying human diamine sensors for death related putrescine and cadaverine molecules". PLOS Computational Biology. 14 (1): e1005945. Bibcode:2018PLSCB..14E5945I. doi:10.1371/journal.pcbi.1005945. PMC 5783396. PMID 29324768.
10. Kuvarzin S, Leonova E, Efimova E, Gainetdinov R (December 2019). "Identifying the function of trace amine-associated receptor 6 and its role in behavior, physiology and brain neurochemistry". European Neuropsychopharmacology. Elsevier. 29: S93. doi:10.1016/j.euroneuro.2019.09.164. S2CID 209352329.

Further reading

• Cao Q, Martinez M, Zhang J, Sanders AR, Badner JA, Cravchik A, et al. (July 1997). "Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees". Genomics. 43 (1): 1–8. doi:10.1006/geno.1997.4815. PMID 9226366.
• Kaufmann CA, Suarez B, Malaspina D, Pepple J, Svrakic D, Markel PD, et al. (July 1998). "NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees". American Journal of Medical Genetics. 81 (4): 282–9. doi:10.1002/(SICI)1096-8628(19980710)81:4<282::AID-AJMG2>3.0.CO;2-W. PMID 9674972.
• Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, et al. (July 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proceedings of the National Academy of Sciences of the United States of America. 98 (16): 8966–71. doi:10.1073/pnas.151105198. PMC 55357. PMID 11459929.
• Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, et al. (October 2004). "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia". American Journal of Human Genetics. 75 (4): 624–38. doi:10.1086/424887. PMC 1182049. PMID 15329799.
• Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
• Amann D, Avidan N, Kanyas K, Kohn Y, Hamdan A, Ben-Asher E, et al. (February 2006). "The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23". Molecular Psychiatry. 11 (2): 119–21. doi:10.1038/sj.mp.4001752. PMID 16189505. S2CID 43731573.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.