GPRC5A

Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene.[5][6]

GPRC5A
Identifiers
Aliases	GPRC5A, GPCR5A, RAI3, RAIG1, PEIG-1, TIG1, G protein-coupled receptor class C group 5 member A
External IDs	OMIM: 604138 MGI: 1891250 HomoloGene: 2961 GeneCards: GPRC5A
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.1 Start 12,890,782 bp[1] End 12,917,937 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G1 Start 135,065,651 bp[2] End 135,084,709 bp[2]
Gene ontology Molecular function • G-protein coupled receptor activity • GO:0001948 protein binding • signal transducer activity • cadherin binding • protein kinase activator activity Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • extracellular exosome • cytoplasmic vesicle membrane • intracellular membrane-bounded organelle • membrane • cytoplasmic vesicle • vesicle • nucleolus • receptor complex Biological process • negative regulation of epidermal growth factor-activated receptor activity • G-protein coupled receptor signaling pathway • signal transduction • activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9052	232431
Ensembl	ENSG00000013588	ENSMUSG00000046733
UniProt	Q8NFJ5	Q8BHL4
RefSeq (mRNA)	NM_003979	NM_181444
RefSeq (protein)	NP_003970	NP_852109
Location (UCSC)	Chr 12: 12.89 – 12.92 Mb	Chr 6: 135.07 – 135.08 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the type 3 G protein-coupled receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoic acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.[6]

Post transcriptional regulation

GPRC5A is one of only a handful of genes known in the literature that are post-transcriptionally controlled by miRNAs through their 5'UTR.[7]

Clinical significance

GPRC5A is dysregulated in many human cancers and in other diseases.[8]

See also

• Retinoic acid-inducible orphan G protein-coupled receptor

References

1. GRCh38: Ensembl release 89: ENSG00000013588 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046733 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.
6. "Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A".
7. Zhou H, Rigoutsos I (2014). "MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells". RNA. 20 (9): 1431–9. doi:10.1261/rna.045757.114. PMC 4138326. PMID 24984703.
8. Zhou H, Rigoutsos I (2014). "The emerging roles of GPRC5A in diseases". Oncoscience. 1 (12): 765–76. doi:10.18632/oncoscience.104. PMC 4303886. PMID 25621293.

Further reading

• Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA (1996). "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells". Cell. Mol. Biol. (Noisy-le-grand). 42 (5): 797–804. PMID 8832110.
• Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
• Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.
• Tao Q, Cheng Y, Clifford J, Lotan R (2004). "Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid". Genomics. 83 (2): 270–80. doi:10.1016/S0888-7543(03)00237-4. PMID 14706456.
• Wu Q, Ding W, Mirza A, Van Arsdale T, Wei I, Bishop WR, Basso A, McClanahan T, Luo L, Kirschmeier P, Gustafson E, Hernandez M, Liu S (2005). "Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target". J. Biol. Chem. 280 (13): 12935–43. doi:10.1074/jbc.M409901200. PMID 15659406.
• Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Hirano M, Zang L, Oka T, Ito Y, Shimada Y, Nishimura Y, Tanaka T (2006). "Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression". Biochem. Biophys. Res. Commun. 351 (1): 185–91. doi:10.1016/j.bbrc.2006.10.016. PMID 17055459.

External links

• "GPRC5 Receptors: RAIG₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.