GPR101

Probable G-protein coupled receptor 101 is a protein that in humans is encoded by the GPR101 gene.[5][6]

GPR101
Identifiers
Aliases	GPR101, GPCR6, PAGH2, G protein-coupled receptor 101, PITA2
External IDs	OMIM: 300393 MGI: 2685211 HomoloGene: 14273 GeneCards: GPR101
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.3 Start 137,027,447 bp[1] End 137,033,847 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A6 Start 57,496,668 bp[2] End 57,503,757 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • adrenergic receptor activity Cellular component • integral component of membrane • receptor complex • cell membrane • integral component of plasma membrane • membrane • intracellular Biological process • adenylate cyclase-activating adrenergic receptor signaling pathway • cell-cell signaling • G-protein coupled receptor signaling pathway • signal transduction • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83550	245424
Ensembl	ENSG00000165370	ENSMUSG00000036357
UniProt	Q96P66	Q80T62
RefSeq (mRNA)	NM_054021	NM_001033360
RefSeq (protein)	NP_473362	NP_001028532
Location (UCSC)	Chr X: 137.03 – 137.03 Mb	Chr X: 57.5 – 57.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[6]

Clinical significance

A duplication event in GPR101 is implicated in cases of gigantism and acromegaly.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000165370 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036357 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
6. "Entrez Gene: GPR101 G protein-coupled receptor 101".
7. Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra MD, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA (2014). "Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation". N. Engl. J. Med. 371 (25): 2363–74. doi:10.1056/NEJMoa1408028. PMC 4291174. PMID 25470569.

Further reading

• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.