GPR156

GPR156 (G protein-coupled receptor 156), is a human gene which encodes a G protein-coupled receptor belonging to metabotropic glutamate receptor subfamily.[5] By sequence homology, this gene was proposed as being a possible GABA_B receptor subunit, however when expressed in cells alone or with other GABA_B subunits, no response to GABA_B ligands could be detected. Therefore, the function of this protein remains to be elucidated.[6]

GPR156
Identifiers
Aliases	GPR156, GABABL, PGR28, G protein-coupled receptor 156
External IDs	OMIM: 610464 MGI: 2653880 HomoloGene: 17683 GeneCards: GPR156
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.33 Start 120,164,645 bp[1] End 120,285,094 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 37,916,496 bp[2] End 38,007,530 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • G-protein coupled GABA receptor activity • signal transducer activity Cellular component • integral component of membrane • membrane • cell membrane • G-protein coupled receptor heterodimeric complex Biological process • G-protein coupled receptor signaling pathway • signal transduction • gamma-aminobutyric acid signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	165829	239845
Ensembl	ENSG00000175697	ENSMUSG00000046961
UniProt	Q8NFN8	Q6PCP7
RefSeq (mRNA)	NM_001168271 NM_153002	NM_153394
RefSeq (protein)	NP_001161743 NP_694547	NP_700443
Location (UCSC)	Chr 3: 120.16 – 120.29 Mb	Chr 16: 37.92 – 38.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000175697 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046961 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR156 G protein-coupled receptor 156".
6. Calver AR, Michalovich D, Testa TT, Robbins MJ, Jaillard C, Hill J, Szekeres PG, Charles KJ, Jourdain S, Holbrook JD, Boyfield I, Patel N, Medhurst AD, Pangalos MN (2003). "Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor". Brain Res. Mol. Brain Res. 110 (2): 305–17. doi:10.1016/S0169-328X(02)00662-9. PMID 12591167.

Further reading

• Calver AR, Michalovich D, Testa TT, Robbins MJ, Jaillard C, Hill J, Szekeres PG, Charles KJ, Jourdain S, Holbrook JD, Boyfield I, Patel N, Medhurst AD, Pangalos MN (2003). "Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor". Brain Res. Mol. Brain Res. 110 (2): 305–17. doi:10.1016/S0169-328X(02)00662-9. PMID 12591167.
• Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.