MRGPRX2

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene.[5][6] Agonists are gyrase inhibitors like ciprofloxacin and non-steroidal neuromuscular blocking agents like atracurium as well as vancomycin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions.

MRGPRX2
Identifiers
Aliases	MRGPRX2, MGRG3, MRGX2, MAS related GPR family member X2
External IDs	OMIM: 607228 MGI: 3588270 HomoloGene: 24986 GeneCards: MRGPRX2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.1 Start 19,054,455 bp[1] End 19,060,717 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B4 Start 48,478,619 bp[2] End 48,499,321 bp[2]
Gene ontology Molecular function • neuropeptide binding • signal transducer activity • mast cell secretagogue receptor activity • G-protein coupled receptor activity Cellular component • cell membrane • membrane • integral component of membrane • mast cell granule • integral component of plasma membrane Biological process • sleep • positive regulation of cytokinesis • mast cell activation • G-protein coupled receptor signaling pathway • signal transduction • nociception • mast cell degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117194	243978
Ensembl	ENSG00000183695	ENSMUSG00000074109
UniProt	Q96LB1	Q3UG50
RefSeq (mRNA)	NM_001303615 NM_054030	NM_001034868
RefSeq (protein)	NP_001290544 NP_473371	NP_001030040
Location (UCSC)	Chr 11: 19.05 – 19.06 Mb	Chr 7: 48.48 – 48.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• MAS1 oncogene

References

1. GRCh38: Ensembl release 89: ENSG00000183695 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074109 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–632. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509.
6. "Entrez Gene: MRGPRX2 MAS-related GPR, member X2".

Further reading

• Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Robas N, Mead E, Fidock M (2004). "MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion". J. Biol. Chem. 278 (45): 44400–44404. doi:10.1074/jbc.M302456200. PMID 12915402.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yang S, Liu Y, Lin AA, et al. (2005). "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception". Gene. 352: 30–35. doi:10.1016/j.gene.2005.03.001. PMID 15862286.