GPR6

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.[5][6]

GPR6
Identifiers
Aliases	GPR6, G protein-coupled receptor 6
External IDs	OMIM: 600553 MGI: 2155249 HomoloGene: 38026 GeneCards: GPR6
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 109,978,256 bp[1] End 109,980,718 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B1|10 22.08 cM Start 41,069,977 bp[2] End 41,072,285 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • sphingosine-1-phosphate receptor activity • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane Biological process • positive regulation of cytosolic calcium ion concentration • G-protein coupled receptor signaling pathway • sphingosine-1-phosphate signaling pathway • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2830	140741
Ensembl	ENSG00000146360	ENSMUSG00000046922
UniProt	P46095	Q6YNI2
RefSeq (mRNA)	NM_005284 NM_001286099	NM_199058
RefSeq (protein)	NP_001273028 NP_005275	NP_951013
Location (UCSC)	Chr 6: 109.98 – 109.98 Mb	Chr 10: 41.07 – 41.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.[7]

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[8]

See also

• Lysophospholipid receptor

References

1. GRCh38: Ensembl release 89: ENSG00000146360 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046922 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR6 G protein-coupled receptor 6".
6. Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.
7. Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling. 14 (11): 941–53. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620.
8. Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry. 282 (14): 10506–15. doi:10.1074/jbc.M700911200. PMID 17284443.

Further reading

• Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA Cell Biol. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID 7832990.
• Song ZH, Modi W, Bonner TI (1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Uhlenbrock K, Huber J, Ardati A, et al. (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cell. Physiol. Biochem. 13 (2): 75–84. doi:10.1159/000070251. PMID 12649592. S2CID 45156405.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• "GPR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.