Prokineticin receptor 2

Prokineticin receptor 2 (PKR₂), is a G protein-coupled receptor encoded by the PROKR2 gene in humans.[5]

PROKR2
Identifiers
Aliases	PROKR2, GPR73L1, GPR73b, GPRg2, HH3, KAL3, PKR2, dJ680N4.3, prokineticin receptor 2
External IDs	OMIM: 607123 MGI: 2181363 HomoloGene: 16368 GeneCards: PROKR2
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p12.3 Start 5,302,040 bp[1] End 5,314,369 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F2 Start 132,337,733 bp[2] End 132,385,447 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • neuropeptide Y receptor activity • pancreatic polypeptide receptor activity • G-protein coupled receptor activity Cellular component • membrane • integral component of membrane • cell membrane • integral component of plasma membrane Biological process • circadian rhythm • signal transduction • neuropeptide signaling pathway • chemical synaptic transmission • feeding behavior • blood circulation • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	128674	246313
Ensembl	ENSG00000101292	ENSMUSG00000050558
UniProt	Q8NFJ6	Q8K458
RefSeq (mRNA)	NM_144773	NM_144944
RefSeq (protein)	NP_658986	NP_659193
Location (UCSC)	Chr 20: 5.3 – 5.31 Mb	Chr 2: 132.34 – 132.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.[5]

Mutations in the PROKR2 (also known as KAL3) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.[6]

See also

• Prokineticin receptor
• Kallmann syndrome

References

1. GRCh38: Ensembl release 89: ENSG00000101292 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050558 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PROKR2 prokineticin receptor 2".
6. Narula HS, Carlson HE (November 2014). "Gynaecomastia--pathophysiology, diagnosis and treatment". Nature Reviews. Endocrinology. 10 (11): 684–98. doi:10.1038/nrendo.2014.139. PMID 25112235. S2CID 40159424.

Further reading

• Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY (May 2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor" (PDF). The Journal of Biological Chemistry. 277 (22): 19276–80. doi:10.1074/jbc.M202139200. PMID 11886876. S2CID 22935718.
• Soga T, Matsumoto Si, Oda T, Saito T, Hiyama H, Takasaki J, Kamohara M, Ohishi T, Matsushime H, Furuichi K (December 2002). "Molecular cloning and characterization of prokineticin receptors". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1579 (2–3): 173–9. doi:10.1016/S0167-4781(02)00546-8. PMID 12427552.
• Battersby S, Critchley HO, Morgan K, Millar RP, Jabbour HN (May 2004). "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle". The Journal of Clinical Endocrinology and Metabolism. 89 (5): 2463–9. doi:10.1210/jc.2003-032012. PMID 15126578.
• Pasquali D, Rossi V, Staibano S, De Rosa G, Chieffi P, Prezioso D, Mirone V, Mascolo M, Tramontano D, Bellastella A, Sinisi AA (September 2006). "The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy". Endocrinology. 147 (9): 4245–51. doi:10.1210/en.2006-0614. PMID 16763065.
• Dodé C, Teixeira L, Levilliers J, Fouveaut C, Bouchard P, Kottler ML, Lespinasse J, Lienhardt-Roussie A, Mathieu M, Moerman A, Morgan G, Murat A, Toublanc JE, Wolczynski S, Delpech M, Petit C, Young J, Hardelin JP (October 2006). "Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2". PLOS Genetics. 2 (10): e175. doi:10.1371/journal.pgen.0020175. PMC 1617130. PMID 17054399.

External links

• GeneReviews/NCBI/NIH/UW entry on Kallmann syndrome
• "Prokineticin Receptors: PKR₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.