Retinoic acid-inducible orphan G protein-coupled receptor

The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid.[1][2][3][4]

G protein-coupled receptor, family C, group 5, member A
Identifiers
Symbol	GPRC5A
Alt. symbols	RAIG1, RAI3
NCBI gene	9052
HGNC	9836
OMIM	604138
RefSeq	NM_003979
UniProt	Q8NFJ5
Other data
Locus	Chr. 12 p13-p12.3
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G protein coupled receptor, family C, group 5, member B
Identifiers
Symbol	GPRC5B
Alt. symbols	RAIG2
NCBI gene	51704
HGNC	13308
OMIM	605948
RefSeq	NM_016235
UniProt	Q9NZH0
Other data
Locus	Chr. 16 p12
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G protein-coupled receptor, family C, group 5, member C
Identifiers
Symbol	GPRC5C
Alt. symbols	RAIG3
NCBI gene	55890
HGNC	13309
OMIM	605949
RefSeq	NM_022036
UniProt	Q9NQ84
Other data
Locus	Chr. 17 q25
Search for Structures Swiss-model Domains InterPro

G protein-coupled receptor, family C, group 5, member D
Identifiers
Symbol	GPRC5D
NCBI gene	55507
HGNC	13310
OMIM	607437
RefSeq	NM_018654
UniProt	Q9NZD1
Other data
Locus	Chr. 12 p13.3
Search for Structures Swiss-model Domains InterPro

The exact function of these proteins has not been determined but they may provide a mechanism by which retinoic acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein-coupled receptors and appear to activate the Wnt signaling pathway.[5]

References

1. Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.
2. Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
3. Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.
4. Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochim. Biophys. Acta. 1518 (3): 237–48. doi:10.1016/s0167-4781(01)00197-x. PMID 11311935.
5. Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). "Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling". Biochem. Biophys. Res. Commun. 358 (4): 968–75. doi:10.1016/j.bbrc.2007.04.208. PMC 2854581. PMID 17521608.

External links

• "GPRC5 (RAIG) Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• GPRC5A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• GPRC5B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• GPRC5C+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)