MRGPRX3

Mas-related G-protein coupled receptor member X3 is a protein that in humans is encoded by the MRGPRX3 gene.[5][6]

MRGPRX3
Identifiers
Aliases	MRGPRX3, GPCR, MRGX3, SNSR1, SNSR2, MAS related GPR family member X3
External IDs	OMIM: 607229 MGI: 3033148 HomoloGene: 79615 GeneCards: MRGPRX3
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.1 Start 18,120,955 bp[1] End 18,138,480 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 47,234,861 bp[2] End 47,252,848 bp[2]
Gene ontology Molecular function • signal transducer activity • G-protein coupled receptor activity Cellular component • cell membrane • membrane • integral component of membrane • integral component of plasma membrane Biological process • G-protein coupled receptor signaling pathway • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117195	668725
Ensembl	ENSG00000179826	ENSMUSG00000074111
UniProt	Q96LB0	n/a
RefSeq (mRNA)	NM_054031 NM_001370464	NM_001177566 NM_001288801
RefSeq (protein)	NP_473372 NP_001357393	n/a
Location (UCSC)	Chr 11: 18.12 – 18.14 Mb	Chr 7: 47.23 – 47.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• MAS1 oncogene

References

1. GRCh38: Ensembl release 89: ENSG00000179826 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074111 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–32. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509. S2CID 14119088.
6. "Entrez Gene: MRGPRX3 MAS-related GPR, member X3".

Further reading

• Lembo PM, Grazzini E, Groblewski T, et al. (2002). "Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs". Nat. Neurosci. 5 (3): 201–9. doi:10.1038/nn815. PMID 11850634. S2CID 42544746.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kaisho Y, Watanabe T, Nakata M, et al. (2005). "Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype". Biochem. Biophys. Res. Commun. 330 (3): 653–7. doi:10.1016/j.bbrc.2005.03.027. PMID 15809047.