P2RY10

Putative P2Y purinoceptor 10 is a protein that, in humans, is encoded by the P2RY10 gene.[5][6][7]

P2RY10
Identifiers
Aliases	P2RY10, LYPSR2, P2Y10, purinergic receptor P2Y10, P2Y receptor family member 10
External IDs	OMIM: 300529 MGI: 1926076 HomoloGene: 8717 GeneCards: P2RY10
Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.1 Start 78,945,332 bp[1] End 78,963,727 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X D Start 107,088,492 bp[2] End 107,104,974 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled purinergic nucleotide receptor activity • signal transducer activity • G-protein coupled receptor activity Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane Biological process • signal transduction • G-protein coupled purinergic nucleotide receptor signaling pathway • positive regulation of Rho protein signal transduction • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27334	78826
Ensembl	ENSG00000078589	ENSMUSG00000050921
UniProt	O00398	Q8BFU7
RefSeq (mRNA)	NM_014499 NM_198333 NM_001324218 NM_001324221 NM_001324225	NM_172435 NM_001357810
RefSeq (protein)	NP_001311147 NP_001311150 NP_001311154 NP_055314 NP_938147	NP_766023 NP_001344739
Location (UCSC)	Chr X: 78.95 – 78.96 Mb	Chr X: 107.09 – 107.1 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene belongs to the family of G-protein coupled receptors that is preferentially activated by adenosine and uridine nucleotides. Two alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.[7]

See also

• P2Y receptor

References

1. GRCh38: Ensembl release 89: ENSG00000078589 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050921 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (June 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
6. Ralevic V, Burnstock G (September 1998). "Receptors for purines and pyrimidines". Pharmacological Reviews. 50 (3): 413–92. PMID 9755289.
7. "Entrez Gene: P2RY10 purinergic receptor P2Y, G-protein coupled, 10".

Further reading

• Berchtold S, Ogilvie AL, Bogdan C, Mühl-Zürbes P, Ogilvie A, Schuler G, Steinkasserer A (September 1999). "Human monocyte derived dendritic cells express functional P2X and P2Y receptors as well as ecto-nucleotidases". FEBS Letters. 458 (3): 424–8. doi:10.1016/S0014-5793(99)01197-7. PMID 10570953. S2CID 35306561.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.