GPR63

Probable G-protein coupled receptor 63 is a protein that in humans is encoded by the GPR63 gene.[5]

GPR63
Identifiers
Aliases	GPR63, PSP24(beta), PSP24B, G protein-coupled receptor 63
External IDs	OMIM: 606915 MGI: 2135884 HomoloGene: 12759 GeneCards: GPR63
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q16.1 Start 96,794,125 bp[1] End 96,837,477 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A3 Start 24,966,407 bp[2] End 25,009,233 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • molecular function Cellular component • integral component of membrane • receptor complex • membrane • cell nucleus • cytosol • cell membrane Biological process • G-protein coupled receptor signaling pathway • signal transduction • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81491	81006
Ensembl	ENSG00000112218	ENSMUSG00000040372
UniProt	Q9BZJ6	Q9EQQ3
RefSeq (mRNA)	NM_001143957 NM_030784	NM_030733 NM_001379626 NM_001379627
RefSeq (protein)	NP_001137429 NP_110411	NP_109658 NP_001366555 NP_001366556
Location (UCSC)	Chr 6: 96.79 – 96.84 Mb	Chr 4: 24.97 – 25.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][5]

References

1. GRCh38: Ensembl release 89: ENSG00000112218 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040372 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR63 G protein-coupled receptor 63".

Further reading

• Kawasawa Y, Kume K, Nakade S, et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID 11027574.
• Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID 11027575.
• Lee DK, George SR, Cheng R, et al. (2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res. Mol. Brain Res. 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Niedernberg A, Tunaru S, Blaukat A, et al. (2004). "Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63". Cell. Signal. 15 (4): 435–46. CiteSeerX 10.1.1.486.4056. doi:10.1016/S0898-6568(02)00119-5. PMID 12618218.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.