Membrane estrogen receptor

Membrane estrogen receptors (mERs) are a group of receptors which bind estrogen.[1][2] Unlike the estrogen receptor (ER), a nuclear receptor which mediates its effects via genomic mechanisms, mERs are cell surface receptors which rapidly alter cell signaling via modulation of intracellular signaling cascades.[1] Putative mERs include membrane-associated ERα (mERα) and ERβ (mERβ), GPER (GPR30), GPRC6A, ER-X, ERx and Gq-mER.[1][2][3]

The mERs have been reviewed.[4]

See also

References
  1. Soltysik K, Czekaj P (April 2013). "Membrane estrogen receptors - is it an alternative way of estrogen action?". J. Physiol. Pharmacol. 64 (2): 129–42. PMID 23756388.
  2. Micevych PE, Kelly MJ (2012). "Membrane estrogen receptor regulation of hypothalamic function". Neuroendocrinology. 96 (2): 103–10. doi:10.1159/000338400. PMC 3496782. PMID 22538318.
  3. Min Pi, Abby L Parrill, L Darryl Quarles (2010). "GPRC6A mediates the non-genomic effects of steroids". J Biol Chem. 285 (51): 39953-64. doi:10.1074/jbc.M110.158063. PMC 3000977. PMID 20947496
  4. Arnal JF, Lenfant F, Metivier R, Flouriot G, Henrion D, Adlanmerini M, Fontaine C, Gourdy P, Chambon P, Katzenellenbogen B, Katzenellenbogen J (July 2017). "Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications". Physiol Rev. 97 (3): 1045–1087. doi:10.1152/physrev.00024.2016. PMID 28539435.



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