ATF5

Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.[5]

ATF5
Identifiers
Aliases	ATF5, ATFX, HMFN0395, activating transcription factor 5
External IDs	OMIM: 606398 MGI: 2141857 HomoloGene: 32142 GeneCards: ATF5
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,928,702 bp[1] End 49,933,935 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 44,812,256 bp[2] End 44,816,658 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001106 transcription corepressor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • chromatin binding • tubulin binding • kinase binding • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • centrosome • transcription regulator complex • nucleoplasm • microtubule organizing center • cytoskeleton • cell nucleus • cytoplasm • cytosol Biological process • negative regulation of cell cycle G2/M phase transition • regulation of transcription, DNA-templated • olfactory bulb interneuron differentiation • multicellular organism growth • regulation of transcription from RNA polymerase II promoter • negative regulation of apoptotic process • post-embryonic development • transcription, DNA-templated • cerebellar granule cell precursor proliferation • positive regulation of transcription, DNA-templated • regulation of centrosome cycle • circadian rhythm • olfactory bulb interneuron development • regulation of gene expression • olfactory lobe development • negative regulation of transcription, DNA-templated • fat cell differentiation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22809	107503
Ensembl	ENSG00000169136	ENSMUSG00000038539
UniProt	Q9Y2D1	O70191
RefSeq (mRNA)	NM_001193646 NM_001290746 NM_012068	NM_030693
RefSeq (protein)	NP_001180575 NP_001277675 NP_036200	NP_109618
Location (UCSC)	Chr 19: 49.93 – 49.93 Mb	Chr 7: 44.81 – 44.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

First described by Nishizawa and Nagata,[6] ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family.[7][8]

ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types.

ATF5 expression is regulated at both the transcriptional and translational level.

ATF5 is expressed in VZ and SVZ during brain development.

The human ATF5 protein is made up of 282 amino acids.

ATF5 is a transcription factor that contains a bZip domain.

See also

• Activating transcription factor

Interactions

ATF5 has been shown to interact with DISC1[9] and TRIB3.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000169136 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038539 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ATF5 activating transcription factor 5".
6. Pati D, Meistrich ML, Plon SE (July 1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. doi:10.1128/mcb.19.7.5001. PMC 84326. PMID 10373550.
7. Hai T, Hartman MG (July 2001). "The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis". Gene. 273 (1): 1–11. doi:10.1016/S0378-1119(01)00551-0. PMID 11483355.
8. Vinson C, Myakishev M, Acharya A, Mir AA, Moll JR, Bonovich M (September 2002). "Classification of human B-ZIP proteins based on dimerization properties". Mol. Cell. Biol. 22 (18): 6321–6335. doi:10.1128/MCB.22.18.6321-6335.2002. PMC 135624. PMID 12192032.
9. Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–1608. doi:10.1093/hmg/ddg162. PMID 12812986.
10. Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–948. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110.

Further reading

• Pati D, Meistrich ML, Plon SE (1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. doi:10.1128/mcb.19.7.5001. PMC 84326. PMID 10373550.
• White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH (2001). "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–13972. doi:10.1073/pnas.240452197. PMC 17684. PMID 11087824.
• Peters CS, Liang X, Li S, Kannan S, Peng Y, Taub R, Diamond RH (2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J. Biol. Chem. 276 (17): 13718–26. doi:10.1074/jbc.M011562200. PMID 11278933.
• Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–1608. doi:10.1093/hmg/ddg162. PMID 12812986.
• Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–5911. doi:10.1038/sj.onc.1207782. PMID 15221005.
• Liu W, Sun M, Jiang J, Shen X, Sun Q, Liu W, Shen H, Gu J (2004). "Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity". Biochem. Biophys. Res. Commun. 321 (4): 954–960. doi:10.1016/j.bbrc.2004.07.053. PMID 15358120.
• Forgacs E, Gupta SK, Kerry JA, Semmes OJ (2005). "The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription". J. Virol. 79 (11): 6932–6939. doi:10.1128/JVI.79.11.6932-6939.2005. PMC 1112100. PMID 15890932.
• Al Sarraj J, Vinson C, Thiel G (2005). "Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP". Biol. Chem. 386 (9): 873–879. doi:10.1515/BC.2005.102. PMID 16164412. S2CID 24061972.
• Angelastro JM, Canoll PD, Kuo J, Weicker M, Costa A, Bruce JN, Greene LA (2006). "Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5". Oncogene. 25 (6): 907–916. doi:10.1038/sj.onc.1209116. PMID 16170340.
• Wei Y, Jiang J, Sun M, Chen X, Wang H, Gu J (2006). "ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells". Biochem. Biophys. Res. Commun. 339 (2): 591–596. doi:10.1016/j.bbrc.2005.11.054. PMID 16300731.
• Kakiuchi C, Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, Mori N, Fujii K, Yamada K, Yoshikawa T, Kato T (2007). "Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder". Neurosci. Lett. 417 (3): 316–321. doi:10.1016/j.neulet.2007.02.054. PMID 17346882. S2CID 7488805.
• Watatani Y, Ichikawa K, Nakanishi N, Fujimoto M, Takeda H, Kimura N, Hirose H, Takahashi S, Takahashi Y (2008). "Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region". J. Biol. Chem. 283 (5): 2543–2553. doi:10.1074/jbc.M707781200. PMID 18055463.

External links

• ATF5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human ATF5 genome location and ATF5 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.