POU4F3

POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene.[4][5]

POU4F3
Identifiers
Aliases	POU4F3, BRN3C, DFNA15, POU class 4 homeobox 3, DFNA42, DFNA52
External IDs	OMIM: 602460 MGI: 102523 HomoloGene: 2023 GeneCards: POU4F3
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 146,338,839 bp[1] End 146,341,728 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nucleoplasm • cell nucleus • cytoplasm Biological process • regulation of transcription, DNA-templated • sensory perception of sound • inner ear development • visual perception • transcription from RNA polymerase II promoter • transcription, DNA-templated • cell differentiation • positive regulation of transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter • vestibulocochlear nerve development • retinal ganglion cell axon guidance • inner ear morphogenesis • auditory receptor cell differentiation • axon extension • neuromuscular process controlling balance • neuron apoptotic process • inner ear receptor cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5459	18998
Ensembl	ENSG00000091010	ENSMUSG00000024497
UniProt	Q15319	Q63955
RefSeq (mRNA)	NM_002700	NM_138945
RefSeq (protein)	NP_002691	NP_620395
Location (UCSC)	Chr 5: 146.34 – 146.34 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000091010 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Vahava O, Morell R, Lynch ED, Weiss S, Kagan ME, Ahituv N, Morrow JE, Lee MK, Skvorak AB, Morton CC, Blumenfeld A, Frydman M, Friedman TB, King MC, Avraham KB (Apr 1998). "Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans". Science. 279 (5358): 1950–4. doi:10.1126/science.279.5358.1950. PMID 9506947. S2CID 25291858.
5. "Entrez Gene: POU4F3 POU domain, class 4, transcription factor 3".

Further reading

In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice

• Nolan LS, Jagutpal SS, Cadge BA, et al. (2017). "Identification and functional analysis of common sequence variants in the DFNA15 gene, Brn-3c". Gene. 400 (1–2): 89–97. doi:10.1016/j.gene.2007.05.023. PMID 17611044.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clough RL, Sud R, Davis-Silberman N, et al. (2004). "Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity". Biochem. Biophys. Res. Commun. 324 (1): 372–81. doi:10.1016/j.bbrc.2004.09.074. PMID 15465029.
• Weiss S, Gottfried I, Mayrose I, et al. (2003). "The DFNA15 Deafness Mutation Affects POU4F3 Protein Stability, Localization, and Transcriptional Activity". Mol. Cell. Biol. 23 (22): 7957–64. doi:10.1128/MCB.23.22.7957-7964.2003. PMC 262385. PMID 14585957.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Leonard JH, Cook AL, Van Gele M, et al. (2002). "Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma". Int. J. Cancer. 101 (2): 103–10. doi:10.1002/ijc.10554. PMID 12209986. S2CID 20592545.
• Erkman L, McEvilly RJ, Luo L, et al. (1996). "Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development". Nature. 381 (6583): 603–6. doi:10.1038/381603a0. PMID 8637595. S2CID 37343529.
• Xiang M, Zhou L, Macke JP, et al. (1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons". J. Neurosci. 15 (7 Pt 1): 4762–85. doi:10.1523/JNEUROSCI.15-07-04762.1995. PMC 6577904. PMID 7623109.

External links

• POU4F3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.