HOXB5

Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.[5][6][7]

HOXB5
Identifiers
AliasesHOXB5, HHO.C10, HOX2, HOX2A, HU-1, Hox2.1, homeobox B5
External IDsOMIM: 142960 MGI: 96186 HomoloGene: 37585 GeneCards: HOXB5
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.32Start48,591,257 bp[1]
End48,593,961 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3215

15413

Ensembl

ENSG00000120075

ENSMUSG00000038700

UniProt

P09067

P09079

RefSeq (mRNA)

NM_002147

NM_008268

RefSeq (protein)

NP_002138

NP_032294

Location (UCSC)Chr 17: 48.59 – 48.59 MbChr 11: 96.3 – 96.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000120075 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038700 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  7. "Entrez Gene: HOXB5 homeobox B5".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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