KLF5

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.[4][5]

KLF5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EBT
Identifiers
Aliases	KLF5, BTEB2, CKLF, IKLF, Kruppel-like factor 5 (intestinal), Kruppel like factor 5
External IDs	OMIM: 602903 MGI: 1338056 HomoloGene: 37520 GeneCards: KLF5
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q22.1 Start 73,054,976 bp[1] End 73,077,541 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948 protein binding • nucleic acid binding • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor binding • MRF binding Cellular component • Golgi apparatus • intracellular membrane-bounded organelle • nucleoplasm • cell nucleus • transcription regulator complex Biological process • regulation of microvillus assembly • microvillus assembly • regulation of transcription, DNA-templated • intestinal epithelial cell development • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of transcription, DNA-templated • angiogenesis • skeletal muscle cell differentiation • positive regulation of fat cell differentiation • positive regulation of transcription from RNA polymerase II promoter • cellular response to organic cyclic compound • positive regulation of cell proliferation • cellular response to peptide • cellular response to leukemia inhibitory factor • cell-cell signaling via exosome • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • regulation of gene expression • skeletal muscle satellite cell differentiation • satellite cell activation involved in skeletal muscle regeneration • myotube differentiation involved in skeletal muscle regeneration • skeletal muscle tissue regeneration • positive regulation of transcription by transcription factor localization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	688	12224
Ensembl	ENSG00000102554	ENSMUSG00000005148
UniProt	Q13887	Q9Z0Z7
RefSeq (mRNA)	NM_001730 NM_001286818	NM_009769
RefSeq (protein)	NP_001273747 NP_001721	NP_033899
Location (UCSC)	Chr 13: 73.05 – 73.08 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.[5]

Interactions

KLF5 has been shown to interact with Protein SET.[6]

See also

• Kruppel-like factors

References

1. GRCh38: Ensembl release 89: ENSG00000102554 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii-Kuriyama Y (Apr 1993). "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2". Nucleic Acids Research. 21 (7): 1527–32. doi:10.1093/nar/21.7.1527. PMC 309358. PMID 8479902.
5. "Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)".
6. Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/MCB.23.23.8528-8541.2003. PMC 262669. PMID 14612398.

Further reading

• Ghaleb AM, Nandan MO, Chanchevalap S, Dalton WB, Hisamuddin IM, Yang VW (Feb 2005). "Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation". Cell Research. 15 (2): 92–6. doi:10.1038/sj.cr.7290271. PMC 1317089. PMID 15740636.
• Nagai R, Suzuki T, Aizawa K, Shindo T, Manabe I (Aug 2005). "Significance of the transcription factor KLF5 in cardiovascular remodeling". Journal of Thrombosis and Haemostasis. 3 (8): 1569–76. doi:10.1111/j.1538-7836.2005.01366.x. PMID 16102021.
• McConnell BB, Ghaleb AM, Nandan MO, Yang VW (Jun 2007). "The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology". BioEssays. 29 (6): 549–57. doi:10.1002/bies.20581. PMC 2211634. PMID 17508399.
• Kojima S, Kobayashi A, Gotoh O, Ohkuma Y, Fujii-Kuriyama Y, Sogawa K (Feb 1997). "Transcriptional activation domain of human BTEB2, a GC box-binding factor". Journal of Biochemistry. 121 (2): 389–96. doi:10.1093/oxfordjournals.jbchem.a021600. PMID 9089417.
• Conkright MD, Wani MA, Anderson KP, Lingrel JB (Mar 1999). "A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells". Nucleic Acids Research. 27 (5): 1263–70. doi:10.1093/nar/27.5.1263. PMC 148310. PMID 9973612.
• Shi H, Zhang Z, Wang X, Liu S, Teng CT (Dec 1999). "Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter". Nucleic Acids Research. 27 (24): 4807–15. doi:10.1093/nar/27.24.4807. PMC 148782. PMID 10572182.
• Hoshino Y, Kurabayashi M, Kanda T, Hasegawa A, Sakamoto H, Okamoto E, Kowase K, Watanabe N, Manabe I, Suzuki T, Nakano A, Takase S, Wilcox JN, Nagai R (Nov 2000). "Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis". Circulation. 102 (20): 2528–34. doi:10.1161/01.cir.102.20.2528. PMID 11076828.
• Sun R, Chen X, Yang VW (Mar 2001). "Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation". The Journal of Biological Chemistry. 276 (10): 6897–900. doi:10.1074/jbc.C000870200. PMC 2268089. PMID 11152667.
• Dang DT, Zhao W, Mahatan CS, Geiman DE, Yang VW (Jul 2002). "Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene". Nucleic Acids Research. 30 (13): 2736–41. doi:10.1093/nar/gkf400. PMC 117055. PMID 12087155.
• Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sata M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R (Aug 2002). "Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling". Nature Medicine. 8 (8): 856–63. doi:10.1038/nm738. PMID 12101409. S2CID 34181151.
• Sur I, Undén AB, Toftgård R (Jun 2002). "Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles". European Journal of Cell Biology. 81 (6): 323–34. doi:10.1078/0171-9335-00257. PMID 12113473.
• Chen C, Bhalala HV, Qiao H, Dong JT (Sep 2002). "A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer". Oncogene. 21 (43): 6567–72. doi:10.1038/sj.onc.1205817. PMID 12242654.
• Yang XO, Doty RT, Hicks JS, Willerford DM (Jun 2003). "Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs". Blood. 101 (11): 4492–9. doi:10.1182/blood-2002-08-2579. PMID 12576331.
• Chen C, Bhalala HV, Vessella RL, Dong JT (May 2003). "KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer". The Prostate. 55 (2): 81–8. doi:10.1002/pros.10205. PMID 12661032.
• Zhang Z, Teng CT (Apr 2003). "Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function". Nucleic Acids Research. 31 (8): 2196–208. doi:10.1093/nar/gkg310. PMC 153738. PMID 12682370.
• Ohnishi S, Ohnami S, Laub F, Aoki K, Suzuki K, Kanai Y, Haga K, Asaka M, Ramirez F, Yoshida T (Aug 2003). "Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer". Biochemical and Biophysical Research Communications. 308 (2): 251–6. doi:10.1016/S0006-291X(03)01356-1. PMID 12901861.
• Aizawa K, Suzuki T, Kada N, Ishihara A, Kawai-Kowase K, Matsumura T, Sasaki K, Munemasa Y, Manabe I, Kurabayashi M, Collins T, Nagai R (Jan 2004). "Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB". The Journal of Biological Chemistry. 279 (1): 70–6. doi:10.1074/jbc.M306621200. PMID 14573617.
• Sato T, Kanda T, Iida T, Takahashi T, Kishi S, Hoshino Y (2004). "Immunohistochemical study of surgically excised choroidal neovascular membranes". The Journal of International Medical Research. 31 (5): 402–6. doi:10.1177/147323000303100507. PMID 14587307. S2CID 33670045.

External links

• KLF5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.