CNBP

Cellular nucleic acid-binding protein is a protein that in humans is encoded by the CNBP gene.[5][6][7]

CNBP
Identifiers
Aliases	CNBP, CNBP1, DM2, PROMM, RNF163, ZCCHC22, ZNF9, CCHC-type zinc finger nucleic acid binding protein
External IDs	OMIM: 116955 MGI: 88431 HomoloGene: 2567 GeneCards: CNBP
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.3 Start 129,169,484 bp[1] End 129,183,922 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 87,842,615 bp[2] End 87,851,106 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • nucleic acid binding • zinc ion binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • metal ion binding • DNA binding • single-stranded DNA binding • single-stranded RNA binding • RNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • mRNA binding • translation regulator activity Cellular component • cell nucleus • cytoplasm • endoplasmic reticulum • cytosol Biological process • regulation of transcription, DNA-templated • cholesterol biosynthetic process • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-templated • positive regulation of cell proliferation • negative regulation of transcription from RNA polymerase II promoter • positive regulation of cytoplasmic translation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7555	12785
Ensembl	ENSG00000169714	ENSMUSG00000030057
UniProt	P62633	P53996
RefSeq (mRNA)	NM_003418 NM_001127192 NM_001127193 NM_001127194 NM_001127195 NM_001127196	NM_001109745 NM_001109746 NM_013493 NM_001347325 NM_001355195
RefSeq (protein)	NP_001120664 NP_001120665 NP_001120666 NP_001120667 NP_001120668 NP_003409	NP_001103215 NP_001103216 NP_001334254 NP_038521 NP_001342124
Location (UCSC)	Chr 3: 129.17 – 129.18 Mb	Chr 6: 87.84 – 87.85 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in myotonic dystrophy type 2 (MIM 602668).[supplied by OMIM][7]

References

1. GRCh38: Ensembl release 89: ENSG00000169714 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030057 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lusis AJ, Rajavashisth TB, Klisak I, Heinzmann C, Mohandas T, Sparkes RS (Oct 1990). "Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24". Genomics. 8 (2): 411–4. doi:10.1016/0888-7543(90)90303-C. PMID 2249857.
6. Liquori CL, Ricker K, Moseley ML, Jacobsen JF, Kress W, Naylor SL, Day JW, Ranum LP (Aug 2001). "Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9". Science. 293 (5531): 864–7. doi:10.1126/science.1062125. PMID 11486088. S2CID 30903810.
7. "Entrez Gene: CNBP CCHC-type zinc finger, nucleic acid binding protein".

Further reading

• Rajavashisth TB, Taylor AK, Andalibi A, Svenson KL, Lusis AJ (Aug 1989). "Identification of a zinc finger protein that binds to the sterol regulatory element". Science. 245 (4918): 640–3. Bibcode:1989Sci...245..640R. doi:10.1126/science.2562787. PMID 2562787.
• Flink IL, Morkin E (Oct 1995). "Organization of the gene encoding cellular nucleic acid-binding protein". Gene. 163 (2): 279–82. doi:10.1016/0378-1119(95)00421-2. PMID 7590281.
• Warden CH, Krisans SK, Purcell-Huynh D, Leete LM, Daluiski A, Diep A, Taylor BA, Lusis AJ (Nov 1994). "Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing". Genomics. 24 (1): 14–9. doi:10.1006/geno.1994.1576. PMID 7896269.
• Ricker K, Grimm T, Koch MC, Schneider C, Kress W, Reimers CD, Schulte-Mattler W, Mueller-Myhsok B, Toyka KV, Mueller CR (Jan 1999). "Linkage of proximal myotonic myopathy to chromosome 3q". Neurology. 52 (1): 170–1. doi:10.1212/wnl.52.1.170. PMID 9921867. S2CID 693401.
• McGrath CF, Buckman JS, Gagliardi TD, Bosche WJ, Coren LV, Gorelick RJ (Aug 2003). "Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein". Journal of Virology. 77 (15): 8524–31. doi:10.1128/JVI.77.15.8524-8531.2003. PMC 165261. PMID 12857921.
• Vallo L, Bonifazi E, Borgiani P, Novelli G, Botta A (Feb 2005). "Characterization of a single nucleotide polymorphism in the ZNF9 gene and analysis of association with myotonic dystrophy type II (DM2) in the Italian population". Molecular and Cellular Probes. 19 (1): 71–4. doi:10.1016/j.mcp.2004.09.003. PMID 15652222.
• Botta A, Caldarola S, Vallo L, Bonifazi E, Fruci D, Gullotta F, Massa R, Novelli G, Loreni F (Mar 2006). "Effect of the [CCTG]n repeat expansion on ZNF9 expression in myotonic dystrophy type II (DM2)". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1762 (3): 329–34. doi:10.1016/j.bbadis.2005.11.004. PMID 16376058.
• Margolis JM, Schoser BG, Moseley ML, Day JW, Ranum LP (Jun 2006). "DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression". Human Molecular Genetics. 15 (11): 1808–15. doi:10.1093/hmg/ddl103. PMID 16624843.
• Toth C, Dunham C, Suchowersky O, Parboosingh J, Brownell K (Feb 2007). "Unusual clinical, laboratory, and muscle histopathological findings in a family with myotonic dystrophy type 2". Muscle & Nerve. 35 (2): 259–64. doi:10.1002/mus.20685. PMID 17068784. S2CID 24178593.
• Gerbasi VR, Link AJ (Jun 2007). "The myotonic dystrophy type 2 protein ZNF9 is part of an ITAF complex that promotes cap-independent translation" (PDF). Molecular & Cellular Proteomics. 6 (6): 1049–58. doi:10.1074/mcp.M600384-MCP200. PMID 17327219. S2CID 2018887.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• GeneReviews/NCBI/NIH/UW entry on Myotonic Dystrophy Type 2
• ZNF9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CNBP genome location and CNBP gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.