IKZF2

Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene.[5][6][7]

IKZF2
Identifiers
Aliases	IKZF2, ANF1A2, HELIOS, ZNF1A2, ZNFN1A2, IKAROS family zinc finger 2
External IDs	OMIM: 606234 MGI: 1342541 HomoloGene: 22659 GeneCards: IKZF2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q34 Start 212,999,691 bp[1] End 213,152,427 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C3 Start 69,531,214 bp[2] End 69,687,245 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001948 protein binding • protein homodimerization activity • metal ion binding • protein heterodimerization activity • nucleic acid binding • molecular function • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22807	22779
Ensembl	ENSG00000030419	ENSMUSG00000025997
UniProt	Q9UKS7	P81183
RefSeq (mRNA)	NM_001079526 NM_016260 NM_001371274 NM_001371275 NM_001371276 NM_001371277	NM_011770
RefSeq (protein)	NP_001072994 NP_057344 NP_001358203 NP_001358204 NP_001358205 NP_001358206	NP_035900
Location (UCSC)	Chr 2: 213 – 213.15 Mb	Chr 1: 69.53 – 69.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000030419 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025997 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, Smale ST (Mar 1998). "Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin". Genes & Development. 12 (6): 782–96. doi:10.1101/gad.12.6.782. PMC 316626. PMID 9512513.
6. Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA (Apr 1998). "Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors". Current Biology. 8 (9): 508–15. doi:10.1016/S0960-9822(98)70202-7. PMID 9560339.
7. "Entrez Gene: IKZF2 IKAROS family zinc finger 2 (Helios)".

Further reading

• Rebollo A, Schmitt C (Jun 2003). "Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies". Immunology and Cell Biology. 81 (3): 171–5. doi:10.1046/j.1440-1711.2003.01159.x. PMID 12752680. S2CID 43733744.
• Sridharan R, Smale ST (Oct 2007). "Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes". The Journal of Biological Chemistry. 282 (41): 30227–38. doi:10.1074/jbc.M702541200. PMID 17681952.
• Tabayashi T, Ishimaru F, Takata M, Kataoka I, Nakase K, Kozuka T, Tanimoto M (Feb 2007). "Characterization of the short isoform of Helios overexpressed in patients with T-cell malignancies". Cancer Science. 98 (2): 182–8. doi:10.1111/j.1349-7006.2006.00372.x. PMID 17297655. S2CID 9787574.
• Sun L, Kerawalla H, Wu X, Lehnert MS, Uckun FM (Apr 2002). "Expression of a unique helios isoform in human leukemia cells". Leukemia & Lymphoma. 43 (4): 841–9. doi:10.1080/10428190290016980. PMID 12153174. S2CID 8170745.
• Durand C, Kerfourn F, Charlemagne J, Fellah JS (Jun 2002). "Identification and expression of Helios, a member of the Ikaros family, in the Mexican axolotl: implications for the embryonic origin of lymphocyte progenitors". European Journal of Immunology. 32 (6): 1748–52. doi:10.1002/1521-4141(200206)32:6<1748::AID-IMMU1748>3.0.CO;2-B. PMID 12115658.
• Nakase K, Ishimaru F, Fujii K, Tabayashi T, Kozuka T, Sezaki N, Matsuo Y, Harada M (Apr 2002). "Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia". Experimental Hematology. 30 (4): 313–7. doi:10.1016/S0301-472X(01)00796-2. PMID 11937265.
• Perdomo J, Holmes M, Chong B, Crossley M (Dec 2000). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". The Journal of Biological Chemistry. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.
• Hosokawa Y, Maeda Y, Seto M (Oct 1999). "Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern". Immunogenetics. 50 (1–2): 106–8. doi:10.1007/s002510050696. PMID 10541817. S2CID 39219337.

External links

• IKZF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.