HIVEP1

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.[5][6]

HIVEP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BBO, 4ZNF
Identifiers
Aliases	HIVEP1, CIRIP, CRYBP1, GAAP, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A, human immunodeficiency virus type I enhancer binding protein 1, HIVEP zinc finger 1
External IDs	OMIM: 194540 MGI: 96100 HomoloGene: 1596 GeneCards: HIVEP1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p24.1 Start 12,008,762 bp[1] End 12,164,999 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A4|13 20.72 cM Start 42,052,021 bp[2] End 42,192,537 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948 protein binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • mitochondrion • cell nucleus • nucleoplasm • nuclear body Biological process • multicellular organism development • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • signal transduction • transcription, DNA-templated • BMP signaling pathway • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3096	110521
Ensembl	ENSG00000095951	ENSMUSG00000021366
UniProt	P15822	Q03172
RefSeq (mRNA)	NM_002114	NM_007772
RefSeq (protein)	NP_002105	NP_031798
Location (UCSC)	Chr 6: 12.01 – 12.16 Mb	Chr 13: 42.05 – 42.19 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000095951 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021366 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gaynor RB, Muchardt C, Diep A, Mohandas TK, Sparkes RS, Lusis AJ (Jul 1991). "Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24". Genomics. 9 (4): 758–61. doi:10.1016/0888-7543(91)90371-K. PMID 2037300.
6. "Entrez Gene: HIVEP1 human immunodeficiency virus type I enhancer binding protein 1".

Further reading

• Omichinski JG, Clore GM, Robien M, et al. (1992). "High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1". Biochemistry. 31 (16): 3907–17. doi:10.1021/bi00131a004. PMID 1567844.
• Nakamura T, Donovan DM, Hamada K, et al. (1990). "Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes". Mol. Cell. Biol. 10 (7): 3700–8. doi:10.1128/mcb.10.7.3700. PMC 360816. PMID 1694016.
• Muchardt C, Seeler JS, Nirula A, et al. (1992). "Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products". J. Virol. 66 (1): 244–50. doi:10.1128/JVI.66.1.244-250.1992. PMC 238281. PMID 1727488.
• Fan CM, Maniatis T (1990). "A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence". Genes Dev. 4 (1): 29–42. doi:10.1101/gad.4.1.29. PMID 2106471.
• Baldwin AS, LeClair KP, Singh H, Sharp PA (1990). "A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes". Mol. Cell. Biol. 10 (4): 1406–14. doi:10.1128/mcb.10.4.1406. PMC 362243. PMID 2108316.
• Omichinski JG, Clore GM, Appella E, et al. (1991). "High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution". Biochemistry. 29 (40): 9324–34. doi:10.1021/bi00492a004. PMID 2248949.
• Maekawa T, Sakura H, Sudo T, Ishii S (1989). "Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1". J. Biol. Chem. 264 (25): 14591–3. PMID 2504707.
• Otsuka M, Fujita M, Aoki T, et al. (1995). "Novel zinc chelators with dual activity in the inhibition of the kappa B site-binding proteins HIV-EP1 and NF-kappa B". J. Med. Chem. 38 (17): 3264–70. doi:10.1021/jm00017a011. PMID 7650680.
• Seeler JS, Muchardt C, Suessle A, Gaynor RB (1994). "Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression". J. Virol. 68 (2): 1002–9. doi:10.1128/JVI.68.2.1002-1009.1994. PMC 236538. PMID 8289330.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Wissmüller S, Kosian T, Wolf M, et al. (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC 1421504. PMID 16582099.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

External links

• HIVEP1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.