TEAD3

Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene.[5][6][7]

TEAD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5EMW
Identifiers
Aliases	TEAD3, DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF-5, TEF5, TEA domain transcription factor 3
External IDs	OMIM: 603170 MGI: 109241 HomoloGene: 81821 GeneCards: TEAD3
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.31 Start 35,473,597 bp[1] End 35,497,079 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 14.66 cM Start 28,331,671 bp[2] End 28,350,817 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001948 protein binding • RNA polymerase II transcription factor binding • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nucleoplasm • cell nucleus • transcription regulator complex Biological process • regulation of transcription from RNA polymerase II promoter • female pregnancy • transcription initiation from RNA polymerase II promoter • regulation of transcription, DNA-templated • Hippo signaling pathway • transcription, DNA-templated • asymmetric neuroblast division • positive regulation of transcription from RNA polymerase II promoter • embryonic organ development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7005	21678
Ensembl	ENSG00000007866	ENSMUSG00000002249
UniProt	Q99594	P70210
RefSeq (mRNA)	NM_003214	NM_001098226 NM_001204156 NM_011566
RefSeq (protein)	NP_003205	NP_001091696 NP_001191085 NP_035696
Location (UCSC)	Chr 6: 35.47 – 35.5 Mb	Chr 17: 28.33 – 28.35 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.[8] Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4. TEAD3 is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos.[9] Translation of this protein is initiated at a non-AUG (AUA) start codon.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000007866 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002249 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Jan 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics. 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009.
6. Jacquemin P, Martial JA, Davidson I (May 1997). "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer". The Journal of Biological Chemistry. 272 (20): 12928–37. doi:10.1074/jbc.272.20.12928. PMID 9148898.
7. "Entrez Gene: TEAD3 TEA domain family member 3".
8. Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell. 66 (1): 11–12. doi:10.1016/0092-8674(91)90132-I. PMID 2070413. S2CID 2819591.
9. Mann CJ, Osborn DP, Hughes SM (Oct 2007). "Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord". Gene Expression Patterns. 7 (8): 827–36. doi:10.1016/j.modgep.2007.08.001. PMC 3360971. PMID 17916448.

Further reading

• Jiang SW, Wu K, Eberhardt NL (Jun 1999). "Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer". Molecular Endocrinology. 13 (6): 879–89. doi:10.1210/me.13.6.879. PMID 10379887.
• Vaudin P, Delanoue R, Davidson I, Silber J, Zider A (Nov 1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation". Development. 126 (21): 4807–16. PMID 10518497.
• Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML (May 2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm". Genes & Development. 15 (10): 1229–41. doi:10.1101/gad.888601. PMC 313800. PMID 11358867.
• Maeda T, Mazzulli JR, Farrance IK, Stewart AF (Jul 2002). "Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes". The Journal of Biological Chemistry. 277 (27): 24346–52. doi:10.1074/jbc.M201171200. PMID 11986313.
• Peng L, Huang Y, Jin F, Jiang SW, Payne AH (Aug 2004). "Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1". Molecular Endocrinology. 18 (8): 2049–60. doi:10.1210/me.2004-0028. PMC 3273420. PMID 15131259.

External links

• TEAD3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)