MEOX2

Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.[5][6]

MEOX2
Identifiers
Aliases	MEOX2, GAX, MOX2, mesenchyme homeobox 2
External IDs	OMIM: 600535 MGI: 103219 HomoloGene: 4330 GeneCards: MEOX2
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p21.2 Start 15,611,212 bp[1] End 15,686,683 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A3|12 16.84 cM Start 37,108,540 bp[2] End 37,179,534 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • sequence-specific DNA binding • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • nuclear speck • cell nucleus Biological process • neuron death • palate development • regulation of transcription, DNA-templated • somite specification • blood circulation • transcription, DNA-templated • limb development • multicellular organism development • angiogenesis • skeletal muscle tissue development • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell migration involved in sprouting angiogenesis • transcription from RNA polymerase II promoter • somite development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4223	17286
Ensembl	ENSG00000106511	ENSMUSG00000036144
UniProt	P50222	P32443
RefSeq (mRNA)	NM_005924	NM_008584
RefSeq (protein)	NP_005915	NP_032610
Location (UCSC)	Chr 7: 15.61 – 15.69 Mb	Chr 12: 37.11 – 37.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[6]

Interactions

MEOX2 has been shown to interact with PAX1[7] and PAX3.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000106511 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036144 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. LePage DF, Altomare DA, Testa JR, Walsh K (May 1995). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics. 24 (3): 535–40. doi:10.1006/geno.1994.1663. PMID 7713505.
6. "Entrez Gene: MEOX2 mesenchyme homeobox 2".
7. Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.

Further reading

• Grigoriou M, Kastrinaki MC, Modi WS, Theodorakis K, Mankoo B, Pachnis V, Karagogeos D (1995). "Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3". Genomics. 26 (3): 550–5. doi:10.1016/0888-7543(95)80174-K. PMID 7607679.
• Reardon W, McManus SP, Summers D, Winter RM (1994). "Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2". Am. J. Med. Genet. 47 (5): 633–6. doi:10.1002/ajmg.1320470510. PMID 8266988.
• Quinn LM, Latham SE, Kalionis B (2000). "The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta". Placenta. 21 Suppl A: S50–4. doi:10.1053/plac.1999.0514. PMID 10831122.
• Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.
• Gorski DH, Leal AJ (2003). "Inhibition of endothelial cell activation by the homeobox gene Gax". J. Surg. Res. 111 (1): 91–9. doi:10.1016/S0022-4804(03)00042-8. PMID 12842453.
• Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV (2005). "Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease". Nat. Med. 11 (9): 959–65. doi:10.1038/nm1287. PMID 16116430. S2CID 12998034.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lin J, Friesen MT, Bocangel P, Cheung D, Rawszer K, Wigle JT (2006). "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10". Mol. Cell. Biochem. 275 (1–2): 75–84. doi:10.1007/s11010-005-0823-3. PMID 16335786. S2CID 30515981.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Chen Y, Leal AD, Patel S, Gorski DH (2007). "The homeobox gene Gax activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences". J. Biol. Chem. 282 (1): 507–17. doi:10.1074/jbc.M606604200. PMC 1865102. PMID 17074759.

External links

• MEOX2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.